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GondolaBio · 9 hours ago

Director, Antibody Development & Engineering

Palo Alto, CA

Full-time

Onsite

Director/Executive

$220K/yr - $250K/yr

8+ years exp

GondolaBio is a biopharmaceutical company focused on developing next-generation therapeutics for genetic diseases. They are seeking a highly motivated scientist to lead antibody discovery efforts, manage CROs, and contribute to regulatory submissions while collaborating with cross-functional teams.

BiotechnologyManufacturingPharmaceutical

Responsibilities

Design, develop and lead multiple antibody discovery campaign efforts with CROs, including biochemical and functional assay screening

Lead antibody engineering efforts for affinity maturation campaigns, developability, and immunological enhancement

Lead the development of preclinical animal models with CROs to assess lead candidates

Engage in scientific discussion with collaborators and management to evaluate ongoing projects

Develop and optimize the SOPs, validation protocols, provide technical assistance and train research associates as needed

Oversee wet lab activities including tissue culture, PBMC isolation, protein expression and purification, functional assays, and flow cytometry

Maintain strong understanding of state-of-the-art protein engineering

Collaborate with cross-functional teams, including DMPK, toxicology, clinical development, regulatory to advance our therapeutic candidates from preclinical stages toward clinical development in a fast-paced, dynamic environment

Represent the program scientifically to internal and external audiences

Contribute to the drafting of translation- and pharmacology-related sections of regulatory documents including INDs

Contribute to due diligence and gap analysis on potential new GondolaBio assets as needed

Qualification

Antibody discoveryAntibody engineeringImmunology skillsProtein engineeringFlow cytometryBiochemical assaysCRO managementFast learnerCommunication skillsTeamworkProblem solving

Required

PhD degree in biochemistry, immunology or related life science field and 8+ years of experience

Experience with antibody discovery, including antibody engineering, antibody affinity maturation, and developability

Hands-on experience with immunology skills including PBMC isolation and macrophage differentiation, ADCP/ADCC/CDC assays, multicolor flow cytometry

Hands-on experience with protein and antibody engineering skills including protein expression and purification, size exclusion chromatography, antibody campaigns and screening, BLI/SPR kinetics and epitope binning

Passion for getting lifesaving medicines into the hands of patients as quickly and efficiently as is humanly possible

Ability to handle multiple projects simultaneously

Ability to work independently and as part of a team

Must be comfortable with ambiguity

Fast (extremely fast) learner

Strong communication skills

Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals

Commitment, drive, and ownership mindset