Genentech · 4 hours ago
2026 Summer Intern - Computational Sciences Center of Excellence - Agentic tool for Optical Pooled Screens
South San Francisco, CA
Internship
Onsite
Intern
$50/hr - $50/hr
Start in 2026 SpringGenentech is a biotechnology company focused on advancing science and ensuring healthcare access. They are seeking a PhD intern in the Computational Sciences Center of Excellence to develop an autonomous agentic system for optimizing data processing in Optical Pooled Screens.
BiotechnologyLife ScienceManufacturing
Responsibilities
Architecture: Design a modular Python-based agent capable of "tool use" (invoking internal binary executables and APIs)
API & Documentation: Build a production-grade interface for the agent. You must prioritize clear, standard communication protocols to ensure the agent can be easily integrated into broader multi-agent workflows
Benchmarking: Establish a rigorous evaluation framework to quantify the agent's ability to converge on optimal processing configurations compared to human experts
Autonomous Pipeline Optimization: Design an agent capable of utilizing our internal OPS CLI and Python tools. The agent must autonomously test hypotheses on raw image data to determine optimal parameters for image stitching, registration, and feature extraction
Agentic Reasoning & Recovery: Implement a robust reasoning loop (e.g., Plan-and-Solve, ReAct) that can interpret structured quality control logs. The system should effectively diagnose failure modes—distinguishing between data anomalies and configuration errors—and self-correct without human intervention
Interoperable System Design: A critical requirement is the ability of this agent to exist within a larger automated ecosystem. You will design and implement a well-documented, standard API (REST/OpenAPI) for the agent. This interface must allow third-party orchestrators or other specialized agents to communicate with your system, submit jobs, and negotiate parameters programmatically
Qualification
Required
Must be pursuing a PhD (enrolled student)
Must have attained a PhD
Computer Sciences, Data Sciences, Artificial Intelligence, Machine Learning, Applied Mathematics, Applied Physics, Computational Biology, Biomedical Engineering, Bioinformatics, Data Engineering
Advanced Expertise in AI Agents: You are currently researching or building complex agentic systems. You have deep knowledge of orchestration frameworks (e.g., LangGraph, AutoGen), state management, and tool-calling patterns
Strong Software Engineering: Expert Python system designer with experience in Model Context Protocol (MCP) and Agent Communication protocol (ACP) implementation
Data Fluency: While biological expertise is not required, you must be comfortable working with high-dimensional data and complex optimization landscapes
Collaborative Mindset: Ability to work at the intersection of two labs, translating computer science concepts into practical solutions for biological discovery
Preferred
Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion
Benefits
Paid holiday time off benefits
Company
Genentech
Genentech is a biotechnology research company that specializes in genetic testing and personalized medicines.
Founded in 1976
10001+ employees
H1B Sponsorship
Genentech has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (167)
2024 (148)
2023 (150)
2022 (178)
2021 (121)
2020 (158)
Funding
Current Stage
Public CompanyTotal Funding
unknown2009-03-26Acquired
1999-07-20IPO
1976-01-01Series Unknown
Leadership Team
Ashley Magargee
CEO
Michael Laird
Vice President
Recent News
2025-12-30
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