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Denali Therapeutics · 2 hours ago

Associate Scientist, Late-Stage Purification Process Development

South San Francisco

Full-time

Onsite

Mid Level

$107K/yr - $131K/yr

3+ years exp

Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases. They are seeking an Associate Scientist to support late-stage downstream process development activities for their large molecule pipeline, focusing on purification process characterization and validation.

BiotechnologyGeneticsHealth DiagnosticsTherapeutics

H1B Sponsor Likely

Responsibilities

Support purification process characterization, validation, PPQ and BLA-enabling activities

Monitor process performance, trend data, and coordinate sample handling from GMP manufacturing campaigns

Extract and organize data for report and submission authoring and contribute to statistical analysis

Support tech transfer for and GMP campaign readiness

Execute lab-scale chromatography and filtration studies to inform late-stage data packages

Execute in-process testing using ELISA, HPLC, UV and SDS-Page based analytics

Summarize key experimental data and document all experiments in an electronic lab notebook in a timely manner

Collaborate closely with colleagues in CMC, Discovery and other functions to achieve project goals

Qualification

Protein characterizationAKTA protein purificationHPLCGMP experienceScientific problem-solvingCritical thinkingCommunication skills

Required

BS/MS in Biology, Biochemistry, Chemical Engineering or related scientific discipline with 3+ years of industry experience

Experience in protein characterization, design of experiments and analytics

Experience monitoring downstream GMP and/or pilot production unit operations

Hands-on experience with AKTA protein purification systems, lab-scale TFF systems and antibody characterization methods including: HPLC, LC/MS, SDS‐PAGE, DLS and other biophysical techniques

Excellent critical thinking, scientific problem-solving and communication skills

Preferred

Prior experience in a late-stage process development setting

Benefits

401k

Healthcare coverage

ESPP

A broad range of other benefits

Company

Denali Therapeutics

Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families.

Founded in 2013

San Francisco, California, USA

501-1000 employees

https://www.denalitherapeutics.com

H1B Sponsorship

Denali Therapeutics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (11)

2024 (14)

2023 (7)

2022 (6)

2021 (5)

2020 (1)

Funding

Current Stage

Public Company

Total Funding

$1.32B

Key Investors

Royalty PharmaBaillie Gifford

2025-12-04Post Ipo Debt· $200M

2024-02-27Post Ipo Equity· $500M

2022-10-19Post Ipo Equity· $275M

Leadership Team

Ryan Watts

CEO

Peter Chin

Sr. Vice President & Head of Late-Stage Clinical Development and Medical Affairs

Recent News

MarketScreener

The New England Journal of Medicine Publishes Phase 1/2 Study of Denali Therapeutics’ Tividenofusp Alfa (DNL310) for Hunter Syndrome (MPS II)

2025-12-30

thefly.com

Denali Therapeutics announces publication of Phase 1/2 study of DNL310

2025-12-30

The Motley Fool

Biggest Stock Movers Today, Dec. 10: PLAB, AVAV, & More

2025-12-11

Company data provided by crunchbase