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Cherokee Federal · 23 hours ago

Biological Scientist

San Antonio, TX

Full-time

Onsite

Mid Level

$75K/yr - $85K/yr

3+ years exp

Cherokee Federal is a company that provides support, services, and solutions to federal and commercial customers. They are seeking a Biological Scientist Journeyman to contribute to the generation and validation of Good Laboratory Practice (GLP) – Candidate Vaccine Viruses (CVVs) for delivery to the Centers of Disease Control and Prevention (CDC). The role involves conducting laboratory techniques, analyzing molecular data, and maintaining GLP standards.

GovernmentNon ProfitProfessional ServicesPublic Relations

No H1B

U.S. Citizen Only

Responsibilities

Conduct laboratory techniques including aseptic cell culture, plasmid preparation, electrophoresis, enzyme digestion, cell transfection, egg inoculation and harvest, generation of vaccine stocks, and QC testing

Analyze molecular data associated with virus replication, innate immune response, host challenge, and pathogenesis

Cloning or synthesizing the HA and NA genes into CDC-provided/approved reverse genetics vectors compatible for virus rescue and preparing high-quality plasmids in compliance with GLP regulations

Perform laboratory research to determine the optimal HA and NA constructs before rescuing each of the GLP-CVV

Perform a hemagglutination assay (HA) using turkey red blood cells to confirm the GLP-CVV stock

Perform an Egg Infectious Dose 50 (EID50) assay to confirm the GLP-CVV stock meets a minimum infectious titer that will be communicated when the information/materials are provided by CDC

Maintain GLP standards and accurate research documentation

Develop draft Standard Operating Protocols (SOPs) in strict accordance with FDA’s 21 CFR 58 GLP regulations, including quality assurance qualification of all laboratory reagents

Prepare Batch Production Records (BPRs) and other quality documents

Review SOPs, BPRs, study reports, and all other related documents

Ensure laboratory operations, inventories, reagent management, and equipment calibration/maintenance always comply

Work with a great deal of independence in achieving research goals

Keep up to date with the latest literature; participate in group meetings to discuss findings

Willingness to work in teams, including those in the Disease Intervention & Prevention Program, Quality Control, and Quality Assessment teams, and with national and international collaborators

Perform other job-related duties as assigned

Qualification

Laboratory Practices (GLP)Cell CultureInfluenza VirusStandard Operating Procedures (SOPs)Quality AssuranceReverse GeneticsTransfectionElectroporationPlasmidsSterility

Required

An active Public Trust or the ability to obtain a Public Trust is required for consideration

Bachelor's degree in Microbiology, Molecular Biology, Virology or Cell Biology required with 3+ years of experience with an active research record

Knowledge of propagation and adaptation of the influenza virus in embryonated chicken eggs

Ability to follow strict protocols and regulations

Great eagerness to solve scientific problems

Excellent time management, organizational skills, and good detail orientation

Ability to work in a team environment

Must pass the pre-employment qualifications of Cherokee Federal

Preferred

Master's degree in Microbiology, Molecular Biology, Virology or Cell Biology with an active research record is preferred

Ideal candidates would have training in basic virology techniques, including virus propagation in cell culture and embryonated chicken eggs, microscopy, cloning, and animal models of infection

At least two years of hands-on experience working with animals and egg-based viral propagation is highly preferred

Experience with GLP regulations and documentation is preferred

Benefits

Medical

Dental

Vision

401K

Other possible benefits as provided

Company

Cherokee Federal

Cherokee Federal, a division of Cherokee Nation Businesses, is a trusted team of government contracting professionals who can rapidly build innovative solutions.

Founded in 1969

Tulsa, Oklahoma, USA

5001-10000 employees