SystImmune · 3 months ago
Scientist/Senior Scientist, Protein Design
Redmond, WA
Full-time
Onsite
Senior Level, Lead/Staff
$150K/yr - $250K/yr
8+ years expSystImmune is a leading and well-funded clinical-stage biopharmaceutical company specializing in developing innovative cancer treatments. They are seeking a creative and motivated Protein Design Scientist or Senior Scientist to enhance their Computational Protein Design pipeline and collaborate with various teams to drive the development of novel therapeutics.
BiopharmaBiotechnologyProfessional Services
Responsibilities
Execute and improve a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approach
Drive assay validation, tech transfer, and development initiatives to maintain industry standards; Contribute within the computational protein design group to operate yeast display-based protein discovery platforms
Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process
Analyze, interpret, document and present data to the scientific and leadership team
Work within a collaborative, and interdisciplinary team to actively contribute to executing the vision of the company
Qualification
Required
PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field
8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required
Applying to solve problems related to peptide and protein design, modeling, and sequence/structure-function prediction, experienced with relevant macromolecular modeling software (i.e. AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger)
Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET)
Preferred
Proven contribution to therapeutic antibody development and selection is desirable
Design and validate novel and biologically relevant antibodies is highly desirable
Benefits
100% paid employee premiums for medical/dental/vision
STD
LTD
401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years
15 PTO days per year
Sick leave
11 paid holidays
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Company
SystImmune
SystImmune is a biotechnology company.
51-200 employees
H1B Sponsorship
SystImmune has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (14)
2023 (1)
2022 (2)
2021 (2)
2020 (1)
Funding
Current Stage
Growth StageLeadership Team
Martin S. Olivo, MD, MSc,
Chief Medical Officer
Recent News
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