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Pharmaron · 4 months ago

Senior Scientist / Associate Principal Scientist, Chemical Engineering R&D

Coventry, Rhode Island, USA, 02816

Full-time

Onsite

Senior Level, Lead/Staff

$100K/yr - $135K/yr

Pharmaron is a global CRO helping pharma and biotech companies bring new therapies to life. The Process Engineer role focuses on process design, scale-up, and tech transfer, working with multidisciplinary teams to develop and optimize pharmaceutical processes.

BiotechnologyChemicalPharmaceutical

Responsibilities

Apply Quality by Design (QbD) principles to early- and late-phase process development

Use Design of Experiments (DoE) for process screening, optimization, and robustness studies

Define CPPs, PARs, NORs, and contribute to the development of scalable control strategies

Evaluate and model kinetics, mixing, mass/heat transfer, and reactor performance

Support development of complex transformations including catalytic hydrogenation

Design and optimize key unit operations including crystallization, filtration, drying, distillation, and extraction

Use process modeling tools to inform scale-up strategies

Translate lab-scale findings into actionable parameters for kilo lab and GMP manufacturing

Drive cycle time reduction and process intensification initiatives

Implement innovative technologies such as continuous flow chemistry and automation platforms

Support internal and external tech transfer activities, including scale-down/up studies, modeling, and verification experiments

Partner with Process Chemistry, Analytical Sciences, Tech Ops, and GMP Production teams

Support integrated programs across Coventry and Pharmaron sites in China (e.g., Tianjin, Shaoxing, Ningbo, Beijing)

Engage in internal and external knowledge sharing, with emphasis on QbD and modeling best practices

Strengthening scale-up and PAT capabilities for robust tech transfer

Advancing continuous processing and flow strategies

Improving manufacturability, cost efficiency, and throughput

Process safety experience very desirable

Qualification

Process DesignReaction EngineeringDownstream ProcessingProcess ModelingQuality by Design (QbD)Design of Experiments (DoE)Technical TransferCommunication SkillsCross-Functional Collaboration