Pleno Inc. · 1 week ago
Senior Bioinformatics Scientist
San Diego County, CA
Full-time
Onsite
Senior Level
$130K/yr - $170K/yr
5+ years expPleno Inc. is a multidisciplinary team focused on revolutionizing biological target detection through a novel multi-omic detection platform. They are seeking a Senior Bioinformatics Scientist to lead the development of advanced statistical and computational methods, particularly in oncology applications and CNV analysis, while collaborating with cross-functional teams to enhance bioinformatics strategies.
BiopharmaBiotechnologyHealth CareHealth Diagnostics
Hiring Manager
Candice Stone
Responsibilities
Lead the development of statistical and machine learning methods for analyzing novel genomic data, with a focus on oncology and CNV detection
Design, implement, and validate CNV and somatic calling algorithms tailored to our platform’s unique data structure
Collaborate with the Biochemistry and Applications teams to build and refine models that enhance assay performance
Participate in the continuous improvement, automation, and scaling of assay design and data analysis
Apply Bayesian inference, hidden Markov models, and other advanced statistical and machine learning techniques to extract meaningful insights from complex multi-omic data
Develop and maintain automated software analysis pipelines
Collaborate on the preparation of scientific presentations and publications of data findings
Qualification
Required
Expertise in statistical modeling, oncology applications, and/or copy number variation (CNV) analysis
Extensive experience working with DNA assays such as NGS sequencing or multiplex PCR applications
Proficiency in oligonucleotide design, as well as sequence interaction prediction and analysis
Strong knowledge of statistical modeling, probabilistic inference, and/or machine learning, particularly in the context of oncology
Experience analyzing multi-omic datasets (e.g., .vcf, .bed, .bam files) and integrating disparate data sources
Proficiency in Python, R, and other relevant programming languages
Familiarity with bioinformatics tools, version control systems (e.g., Git), and cloud-based computing environments
Experience in database development and maintenance
A proven ability to lead projects and collaborate in a multidisciplinary environment
PhD in Bioinformatics, Computational Biology, Statistics, Computer Science, or a related field with 5+ years of progressively responsible industry experience, including demonstrated ownership of bioinformatics method development in oncology and/or statistical genomics
OR MS in Bioinformatics, Computational Biology, Statistics, Computer Science, or a related field, with 8–10+ years of progressively responsible industry experience, including demonstrated ownership of bioinformatics method development in oncology and/or statistical genomics
Preferred
Previous experience working with methylation and/or copy number variant datasets is a plus
Benefits
Equity - everyone at Pleno has a stake in our success
Generous company-sponsored contribution to health, dental and vision coverage
Company contributions to life insurance, short term and long-term disability
Flexible Paid Time Off - plus 11 paid holidays including a winter break company-wide close
Parental Leave - we value our families and include generous parental leave and wage replacement
Free catered onsite meals twice weekly
Fitness and wellness facilities
Regular opportunities to spend social time together like happy hours & team building events - we stop to celebrate our wins
Company
Pleno Inc.
Pleno Inc.
11-50 employees
H1B Sponsorship
Pleno Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2023 (1)
2022 (2)
Funding
Current Stage
Growth StageTotal Funding
$80MKey Investors
Deerfield
2024-12-12Series B· $25M
2022-10-12Series A· $40M
2022-05-25Seed· $15M
Leadership Team
Gavin Stone
Chief Business Officer
Recent News
Tech Funding News
2025-08-21
Company data provided by crunchbase