Crinetics Pharmaceuticals · 2 weeks ago
Vice President, Health Economics and Outcomes Research
United States
Full-time
Onsite
Director/Executive
$350K/yr - $390K/yr
15+ years expCrinetics Pharmaceuticals is a pharmaceutical company based in San Diego, California, focused on developing therapies for endocrine diseases. The Vice President of Health Economics and Outcomes Research will lead the HEOR and RWE strategy, ensuring alignment with market access priorities and overseeing the design of impactful studies to demonstrate the value of the company's portfolio.
BiotechnologyHealth CarePharmaceuticalTherapeutics
Responsibilities
Develop, lead, and operationalize a global HEOR and RWE strategy, embedding advanced real-world data science, digital health, and AI-driven analytics across the product lifecycle to accelerate evidence generation and value demonstration
Serve as the organization’s primary subject matter expert, principal thought leader, and spokesperson on HEOR and RWE, including payer evidence needs, health outcomes trends, and value demonstration strategies
Set the enterprise-wide vision for RWE, including multi-country, multi-source data acquisition strategies including data from insurance claims, electronic health records, patient registries, digital devices, patient apps, and social determinants of health
Oversee external non-employee resources, vendors, and partners to ensure timely, high-quality deliverables aligned with strategic priorities
Build and mentor a high-performing global RWE and HEOR leadership team, fostering a collaborative, mission-driven culture
Manage external research partners, consultants, CROs, and data vendors to ensure delivery of innovative, high-quality work
Lead enterprise-wide training programs on RWE best practices, digital health, and advanced analytics for internal and external stakeholders
Lead the design and execution of HEOR and RWE across U.S. and global markets, ensuring alignment with regulatory, payer, and clinical priorities. This includes: Observational and non-interventional studies leveraging diverse real-world data sources. Integrated analyses of insurance claims and electronic health record (EHR), and patient registries. Advanced economic modeling and linked data evaluations for therapies targeting Acromegaly, Cushing’s disease, and related conditions. Burden-of-illness, treatment pattern, and cost-effectiveness assessments to inform value demonstration. Development and implementation of patient-reported outcomes strategies, including digital health-enabled data capture
Drive innovation in evidence generation, incorporating AI-driven analytics, machine learning, and advanced statistical methodologies to extract actionable insights from complex datasets
Provide strategic direction for payer negotiations and formulary submissions, ensuring evidence packages meet evolving U.S. and international requirements
Lead development of global value dossiers and submissions, integrating RWE and health economic modeling to support pricing and reimbursement strategies across major markets
Lead creation of value communication materials and payer evidence strategies, integrating RWE and advanced health economic modeling
Shape global market access strategies using RWE to inform payer negotiations, formulary positioning, coverage policies, and interactions with research arms of payer organizations
Provide strategic guidance on payer and international HTA bodies (e.g., NICE, CADTH) to influence evidence requirements and policy frameworks as applicable
Drive alignment across Medical Affairs, Clinical Development, Commercial, and Regulatory teams to ensure evidence generation aligns with lifecycle goals and clinical strategy
Collaborate closely with internal stakeholders to ensure evidence generation aligns with lifecycle goals and clinical strategy
Inform clinical trial design to support long-term outcomes and value demonstration
Cultivate relationships with payers, academic partners, HEOR research organizations, and key opinion leaders to advance evidence standards and adoption
Represent the Company at scientific conferences, payer advisory boards, and global forums, positioning the organization as a leader in RWE innovation
Publish and present breakthrough RWE research in peer-reviewed journals and top-tier scientific meetings
Oversee budgets for global RWE initiatives, ensuring optimal resource allocations, timelines, and prioritization decisions
Ensure adherence with global regulatory standards and compliance standards governing HEOR and RWE research and communication
Lead functional planning, including budgeting, resource management, and strategic decision-making to ensure operational excellence across RWE activities
Qualification
Required
Advanced degree (PhD, PharmD, MD, MPH, MS) in Health Economics, Outcomes Research, Epidemiology, Public Health, Biostatistics, Health Services Research, or related field
15+ years of progressive experience in HEOR, RWE, and market access in a global biotechnology, pharmaceutical, or healthcare research settings
Demonstrated leadership of multi-country HEOR/RWE strategies and programs supporting market access, advanced analytics, and digital health initiatives; rare disease or specialty medicine experience strongly preferred
Proven track record in designing and delivering impactful real-world studies and economic models, influencing global regulatory and payer decision-making through innovative RWE
Experience supporting evidence needs for ICER and/or international HTAs (e.g., NICE, CADTH) preferred
Preferred
Strategic thinker with strong analytical, problem-solving, and decision-making skills
Exceptional communication and influence skills; able to engage executive leadership, internal teams, and external stakeholders effectively
Deep understanding of U.S. payer landscape, reimbursement dynamics, and value-based decision frameworks
Familiarity with real-world datasets and data analytics tools (e.g., SAS, R, STATA); strong scientific publications and conference presentation history preferred
Demonstrated ability to thrive in a dynamic, fast-growing, entrepreneurial environment
Benefits
Discretionary annual target bonus
Stock options
ESPP
401k match
Top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
20 days of PTO
10 paid holidays
Winter company shutdown
Company
Crinetics Pharmaceuticals
Crinetics is a clinical-stage pharmaceutical company that develops therapies for people with rare endocrine diseases.
501-1000 employees
Funding
Current Stage
Public CompanyTotal Funding
$2BKey Investors
Frazier Healthcare PartnersNational Institutes of HealthPerceptive Advisors
2026-01-06Post Ipo Equity· $349.22M
2024-10-08Post Ipo Equity· $500M
2024-02-28Post Ipo Equity· $350M
Leadership Team
R. Scott Struthers
Founder, CEO
A
Alan S. Krasner
Chief Endocrinologist
Recent News
BioWorld Financial Watch
2026-01-15
2026-01-07
Company data provided by crunchbase