Pfizer · 2 days ago
Principal Scientist, Pharmaceutical Research & Development
Bothell, WA
Full-time
Onsite
Senior Level, Lead/Staff
$103K/yr - $172K/yr
9+ years expPfizer is a leading pharmaceutical company seeking a Principal Scientist in Pharmaceutical Research & Development. The role involves leading formulation development and physio-chemical characterization efforts for biotherapeutics, requiring strong leadership, communication skills, and a broad understanding of formulation design principles.
BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine
No H1B
Responsibilities
Design, execute, and analyze experiments for existing and novel modalities. Define the appropriate parenteral dosage form, formulation, process design, scale up approaches, identify critical parameters, and define the design space
Support development of novel characterization techniques to characterize formulations to support process development and formulation design
Lead experiments to confirm robust process performance across the control space. Compile experimental and analytical results, perform data interpretation, summarize, and report on data with conclusions and recommended next steps
Provide technical representation and subject matter expertise (SME) in cross functional project teams
Provides leadership and mentorship to matrixed program team colleagues
Collect and share relevant academic literature, leverage external consultants/SMEs, and establish new collaborations with internal groups. Optimize current processes to ensure robust manufacturing of Pfizer’s biotherapeutic portfolio
Interface extensively in a matrixed environment with process and analytical development teams for process investigation support, assess new analytical technologies, support on-going process characterization and post-approval changes
Maintain accountability for project success and results delivery
Communicate research and development findings internally and externally
Qualification
Required
Master of Science degree with 9 or more years of industrial experience; or B.S. with 12 or more years of industrial experience in Pharmacy, Pharmaceutics, Analytical Chemistry, Biophysics, Biomedical Eng, Chemical Eng, Biochemistry, Biotechnology, Biology or equivalent scientific field, or PhD with 2 or more years of directly related industry experience
Experience in formulation development, pharmaceutics, pharmacy or drug product manufacturing or scale-up of biotherapeutics modalities (such as proteins and antibody drug conjugates)
Excellent leadership and/or mentorship skills
Experience with various biophysical and light scattering techniques (DLS, NTA, Coulter Counter, etc.)
Experience with regulatory filings and submissions
Effective communication skills and the ability to write detailed technical reports
Exceptional organizational, communication, and critical thinking skills, and the ability to thrive in an interdependent and idea-rich environment
Strong work ethic and attention to detail
Preferred
PhD with 4 or more years industrial experience in biotherapeutics formulation and process development
Expert understanding and leadership of technical areas necessary for biotherapeutic molecule formulation development
Solid foundation in formulation, analytical, chemistry, material science, and/or nano-particle technologies
Experience in scale-up and technology transfer of aseptic processes to pilot/commercial scale manufacturing facilities
Working knowledge of GLP/GMP requirements
Experience in authoring regulatory submissions (IND, IMPD, BLA, MAA)
Solid understanding of QbD concept in design, execution, and interpretation of formulation and process development experiments
Ability to demonstrate autonomy in representing functional area
Benefits
401(k) plan with Pfizer Matching Contributions
Pfizer Retirement Savings Contribution
Paid vacation
Holiday and personal days
Paid caregiver/parental and medical leave
Health benefits to include medical, prescription drug, dental and vision coverage
Company
Pfizer
Pfizer is a biopharmaceutical company that discovers, develops, and delivers medicines and vaccines.
10001+ employees
Funding
Current Stage
Public CompanyTotal Funding
$38BKey Investors
Starboard Value
2025-11-21Post Ipo Debt· $6B
2024-10-07Post Ipo Equity· $1B
2023-05-16Post Ipo Debt· $31B
Leadership Team
Albert Bourla
Chief Executive Officer
Ian Read
Chief Executive Officer
Recent News
Longevity.Technology
2026-01-09
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