City Therapeutics · 1 week ago
Sr. Scientist/Principal Scientist, Pharmacokinetics
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$136K/yr - $185K/yr
6+ years expCity Therapeutics is a growing biotech company focused on drug discovery and development. They are seeking a highly motivated and skilled PK scientist to join their Translational Sciences Team, where the successful candidate will act as a PK lead for discovery and early development programs, providing insights to drive decision making from drug candidate selection to clinical development.
BiopharmaLife ScienceTherapeutics
Responsibilities
Serve as the PK lead on multidisciplinary teams, partnering with chemistry, platform biology, computational biology, clinical, regulatory, and CMC to advance discovery and early development programs
Apply modeling and simulation approaches (PK/PD, mechanistic, PBPK, QSP) to enable nonclinical to clinical translation, guide dose selection, and inform clinical design
Design and oversee ADME and PKPD studies, both internally and with CROs, to support drug candidate selection and regulatory submissions
Conduct NCA to calculate PK and TK parameters in compliance with GLP and applicable regulatory guidelines to support IND and other regulatory submissions
Prepare high-quality study summaries, technical reports, and input for regulatory documents (e.g. IND, IB, BB, etc)
Integrate DMPK and pharmacology data to build quantitative frameworks to inform structure-activity relationships, target validation, and molecule design
Contribute to program strategy by identifying key risks with quantitative understanding
Stay current with emerging trends in translational modeling and predictive ADME to help implement innovative tools and best practices
Qualification
Required
For Sr. Scientist, Ph.D. (3+ years), MS (7+ years) or BS (9+ years) or for Principal Scientist, Ph.D. (6+ years), MS (10+ years) or BS (12+ years) in pharmacokinetics, pharmaceutical sciences, pharmacology, or related field with prior experience as DMPK lead or translational modeler
Strong experience in translational PK/PD modeling, including PBPK, compartmental, mechanistic modeling
Proficiency with PKPD modeling tools such as Phoenix WinNonlin, MATLAB, R, Simcyp, NONMEM
Strong background in ADME and PK principles
Ability to interpret complex PK data and communicate findings in a clear and concise manner
Familiar with regulatory expectations and guidance relevant to early-stage drug development
Demonstrated adaptability and collaborative mindset with the ability to take on diverse responsibilities in a dynamic environment
Excellent problem-solving and communication skills with the ability to convey complex quantitative data to diverse audiences
Please note this role is required to be on-site at our offices in Cambridge, MA (5 days a week)
Preferred
Prior experience with RNAi or oligonucleotide therapeutics a plus
Experience supporting IND/CTA-enabling studies or early clinical development programs
Experience working with CROs and managing outsourced ADME and PK studies
Benefits
Medical
Dental
Vision
Life insurance
Health and dependent care FSA accounts
HSA/HRA accounts with company contributions
401(k) with competitive company match
Company
City Therapeutics
City Therapeutics is a biopharmaceutical company focused on developing next-generation small interfering RNAs.
11-50 employees
H1B Sponsorship
City Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (4)
2024 (2)
Funding
Current Stage
Early StageTotal Funding
$135MKey Investors
ARCH Venture Partners
2024-10-08Series A· $135M
Leadership Team
Sebastian Trousil
Co-Founder and Chief Operating Officer
Recent News
Company data provided by crunchbase