Gilead Sciences · 1 week ago
Principal Scientist, Protein Therapeutics
San Francisco Bay Area
Full-time
Onsite
Senior Level, Lead/Staff
$196K/yr - $253K/yr
6+ years expGilead Sciences is dedicated to creating a healthier world by developing therapies for major diseases. The Principal Scientist will oversee biologics projects, focusing on the engineering of protein therapeutics and managing multiple discovery projects.
BiopharmaBiotechnologyHealth CareManufacturingPharmaceutical
Responsibilities
Lead a small team of protein engineers to help design and engineer innovative protein therapeutics to address unmet medical needs through differentiated mechanisms of action
Drive rapid optimization of novel antibody and protein therapeutics through iterative design, build, test, and learn cycles
Represent the Protein Therapeutics department on interdisciplinary project teams and guide preclinical development of large molecule therapeutics
Independently carry out lead sequence optimization of large molecules utilizing rational and in silico design approaches, as well as design of multispecifics, immunocytokines, and fusion proteins
Communicate transparently and timely to key stakeholders to build strong partnership and collaboration experiences
Thrive in a fast paced, data-driven, and scientifically rigorous environment
Maintain compliance with company policies and record keeping
Qualification
Required
Ph.D. in biochemistry, structural biology or a related field with 6+ years (postdoctoral training preferred) OR M.S. with 8+ years (16+ years preferred) OR B.S. with 10+ years (18+ years preferred) of additional experience in an academic or industrial setting and a record of accomplishments in the form of high impact publications or patents
Preferred
Extensive experience advancing protein therapeutics from discovery to development and stays abreast with emerging protein engineering platforms and technologies
Expertise in structure-based protein engineering and design of multispecifics, immunocytokines, Fc engineering, and fusion proteins
Skilled practitioner in antibody engineering, including humanization, sequence liability remediation, and/or biophysical property improvement
Project leadership experience in Research across multiple therapeutic areas, with deep understanding of hit-to-lead selection through preclinical development of therapeutic candidates
Presentation and high impact publication record with demonstrable protein engineering expertise
Proficient in various molecular biology and/or library building techniques (e.g. PCR fragment assembly, vector design, site-directed mutagenesis, Gibson assembly, and/or Golden gate cloning), as well as hands-on experience (preferred) with mammalian cell culture, protein expression, purification, and characterization; in vitro and in vivo antibody discovery approaches is a plus
Experience with computational design tools preferred (e.g. Rosetta, MOE, or DiscoveryStudio)
Team player with strong collaboration, communication, organizational skills, and excellent problem-solving skills
Benefits
Discretionary annual bonus
Discretionary stock-based long-term incentives
Paid time off
Company-sponsored medical, dental, vision, and life insurance plans
Company
Gilead Sciences
Gilead Sciences is a biopharmaceutical company that discovers, develops, manufactures and commercializes therapies for critical diseases.
10001+ employees
H1B Sponsorship
Gilead Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (269)
2024 (241)
2023 (222)
2022 (208)
2021 (235)
2020 (187)
Funding
Current Stage
Public CompanyTotal Funding
$4.41BKey Investors
Abingworth
2024-11-13Post Ipo Debt· $3.5M
2024-02-29Post Ipo Equity· $210M
2023-09-07Post Ipo Debt· $2B
Leadership Team
Keeley Wettan
Senior Vice President, Legal
Patrick Loerch
Senior Vice President, Clinical Data Science
Recent News
2026-01-13
Company data provided by crunchbase