Twist Bioscience · 1 day ago
Scientist / Sr Scientist / Staff Scientist - Antibody Platform Development (South San Francisco, CA)
USA - South San Francisco, CA
Full-time
Onsite
Mid, Senior Level, Lead/Staff
$127K/yr - $180K/yr
0+ years expTwist Bioscience is a company focused on synthesizing genes from scratch, contributing to advancements in various fields like health care and agriculture. They are seeking a driven R&D scientist to enhance their antibody development platform, utilizing expertise in molecular biology and analytical techniques to create and improve technologies for antibody discovery and development.
B2BBiotechnologyChemicalHealth CareLife Science
Responsibilities
Develop antibody production, purification and analytical workflows at various scales and throughput, across various formats (single-chain, IgG, multi-specific, Fc-Fusion, etc)
Optimize all aspects of the end-to-end antibody development workflow including but not limited to: construct design, protein expression (transient and stable), purification, and analytics
Independently design and execute experiments, and analyze experimental data
As appropriate, build and lead a team to achieve technical goals
Move projects forward efficiently / manage time and resources effectively / prioritize tasks in accordance with the company’s goals
Document and communicate results clearly and succinctly
Be helpful / collaborative / proactive
Stay up to date with new developments, companies, and technologies
Be the ultimate subject matter expert, and understand all aspects of your work as profoundly as possible, including details that are adjacent to your projects
Qualification
Required
Deep hands-on experience designing, expressing, and optimizing monoclonal antibodies, with demonstrated understanding of Fc structure–function relationships (effector function, stability, manufacturability)
Proven experience with bispecific antibody architectures, including but not limited to: Knob-in-hole, CrossMab, common light chain, or similar; Chain pairing control, mispairing mitigation, and associated analytics
Extensive experience generating and optimizing stable mammalian cell lines (CHO preferred): Vector design, promoter/selection strategies; Clone screening, productivity optimization, and stability assessment
Strong understanding of transient vs stable expression tradeoffs and when to deploy each during platform development
Experience improving expression yields and product quality through sequence, vector, and host engineering
Demonstrated ability to build, improve, and standardize antibody generation workflows
Experience developing high-throughput or semi-automated workflows for expression, purification, and screening
Strong understanding of platform robustness, reproducibility, and cost drivers
Hands-on experience with antibody characterization methods, including but not limited to: SEC, CE-SDS; Binding kinetics (BLI or SPR); Basic biophysical profiling (DSF, DLS); Mass spectrometry
Strong mechanistic understanding of antibody biology, structure, and expression bottlenecks
Experience designing platforms that support multiple antibody modalities (mAbs, bispecifics, Fc-engineered variants)
A track record of successful and creative method development
Advanced degree in Cell Biology, Biochemistry, Chemical Engineering, or a closely-related field
Scientist Requires a PhD and 0-2 years of previous professional experience; or a master's degree and 3-5 years of work experience
Sr Scientist Requires a Ph.D. and 3-5 years of professional experience (postdoc may count); or a master's degree and 7+ years of work experience
Staff Scientist Requires a Ph.D. and 6-10 years of professional experience (postdoc may count); or a master's degree and 10+ years of work experience
Preferred
Familiarity with Python or equivalent programming languages is a plus
Experience with liquid-handling systems and automation is a plus
Benefits
Bonus
Equity
Generous benefits package
Company
Twist Bioscience
Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.
501-1000 employees
H1B Sponsorship
Twist Bioscience has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (14)
2023 (22)
2022 (19)
2021 (4)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$553.11MKey Investors
Capital World InvestorsBiomatics Capital PartnersIllumina
2022-02-09Post Ipo Equity· $250M
2020-01-27Post Ipo Equity· $50M
2018-10-30IPO
Leadership Team
Emily Leproust
CEO
Siyuan Chen
Chief Technology Officer
Recent News
2025-12-30
2025-12-24
Company data provided by crunchbase