Apply on Employer Site

Merck · 4 days ago

Associate Principal Scientist, Antibody Discovery Innovation

South San Francisco, CA

Full-time

Hybrid

Senior Level, Lead/Staff

$156K/yr - $246K/yr

4+ years exp

Merck is committed to being the world’s premier biopharmaceutical company, focusing on breakthrough science to create life-changing medicines. The Associate Principal Scientist will lead initiatives in antibody discovery, optimizing processes and collaborating with cross-functional teams to enhance drug discovery efforts.

BiotechnologyHealth CareMedicalPharmaceutical

Comp. & Benefits

H1B Sponsored

Responsibilities

Propose and lead technology development initiatives to further optimize existing in vivo de novo platforms to increase hits and decrease timelines

Serve as the antibody discovery representative on project teams to help define Target Candidate Profiles (TCP) and lead de novo hit finding strategies and campaigns

Potential for future development opportunities to lead Biologics discovery projects in collaboration with therapeutic area scientists

Stay abreast of external advancements in the relevant scientific fields

Promote the external reputation of our company’s Discovery Biologics department

Qualification

Antibody DiscoveryAdaptive ImmunityB-cell BiologyHigh-Throughput ScreeningMolecular Biology TechniquesInnovationMicrofluidicsTherapeutic AntibodiesProject CoordinationCollaboration SkillsCommunication Skills

Required

Ph.D. with 4+ years or Master's with 8+ years relevant industry experience

Experience in antibody drug discovery supporting therapeutic programs

Excellent communication and collaboration skills

Ability to manage multiple projects simultaneously

Depth of knowledge in adaptive immunity and B-cell biology and direct application towards optimizing antibody drug discovery and development campaigns

Track record of driving scientific and platform innovations

Experience leading therapeutic antibody discovery campaigns

Strong hands-on laboratory skills, including but not limited to cell culture, molecular biology, assay development, and flow cytometry

Established external reputation through publications, presentations, and/or scientific community engagement

Antibody Discovery

Drug Discovery Process

High-Throughput Screening

Innovation

Machine Learning (ML)

Microfluidics

Molecular Biology Techniques

Project Coordination

Team Strategy

Therapeutic Antibodies

Therapeutic Proteins

Preferred

Ideal candidate will have experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, bi- or multi-specifics, fusion proteins, and ADCs