GondolaBio · 1 week ago
Lead Scientist, Electrophysiology (In Vitro / Ex Vivo)
Palo Alto, CA
Full-time
Onsite
Senior Level, Lead/Staff
$150K/yr - $200K/yr
4+ years expGondolaBio is a clinical-stage biopharmaceutical company focused on developing therapeutics for genetic diseases. They are seeking a Lead Scientist in Electrophysiology to advance their rare disease pipeline by designing and interpreting in vitro and ex vivo electrophysiology studies, while mentoring junior scientists and contributing to drug discovery efforts.
BiotechnologyManufacturingPharmaceutical
Responsibilities
Lead the design, execution, and interpretation of in vitro and ex vivo electrophysiology studies to characterize ion channels, transporters, and other excitable membrane proteins
Apply advanced electrophysiology techniques (e.g., patch-clamp, multi-electrode arrays, automated electrophysiology platforms) to study compound mechanism of action, potency, selectivity, and safety liabilities
Develop and validate electrophysiology assays to support drug discovery, including primary cell and tissue slice preparations
Oversee external collaborations with CROs and academic partners to ensure high-quality and timely data delivery
Communicate findings effectively with medicinal chemistry and biology colleagues to guide compound design and optimization
Supervise and mentor junior scientists, building expertise within the team
Stay current with emerging electrophysiology and ion channel drug discovery advances; represent GondolaBio at external meetings and in publications
Contribute to the development of research strategy and integration of electrophysiology insights into broader discovery and translational programs
Qualification
Required
PhD in neuroscience, pharmacology, physiology, or a related field with 2+ years of laboratory experience (postdoc + industry/academic)
2+ years of industry drug discovery experience required, especially collaborations with medicinal chemistry teams to inform SAR
Strong track record applying patch-clamp electrophysiology (manual and automated) or related ex vivo techniques in drug discovery or advanced academic research
Demonstrated experience with ion channels, transporters, or excitable cells/tissues (neurons, cardiomyocytes, muscle fibers, etc.)
Hands-on expertise in designing, executing, and interpreting electrophysiological assays for compound evaluation
Experience managing projects, collaborating cross-functionally, and directing CROs or external partners
Strong problem-solving skills and ability to integrate electrophysiology with other discovery disciplines (structural biology, pharmacology, computational modeling)
Preferred
Experience with tissue slice electrophysiology, synaptic physiology, or stem cell–derived excitable cell models
Familiarity with assay automation, high-throughput electrophysiology platforms, and data analysis pipelines
Broader understanding of preclinical drug discovery disciplines, including cellular disease models, target engagement assays, pharmacology, and PK/PD
Experience mentoring and building an electrophysiology team in an industry setting
Benefits
Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
Flexible PTO
Rapid career advancement for strong performers
Potential ability to work on multiple GondolaBio programs across multiple therapeutic areas over time
Partnerships with leading institutions
Commitment to Diversity, Equity & Inclusion
Company
GondolaBio
GondolaBio researches, develops and manufactures pharmaceutical products. It is a sub-organization of BridgeBio.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$300M2024-08-16Series Unknown· $300M
Leadership Team
J
James Li
President
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