CHEManager International · 1 day ago
Scientist I, Immunology
South San Francisco, CA
Full-time
Onsite
Entry, Mid Level
1+ years expGenEdit is a rapidly-growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. We are seeking a talented and motivated Scientist to join our Immunology team and drive the development of genetic medicines for immune-based diseases utilizing our hydrophilic nanoparticle technology.
Newspapers
Responsibilities
Lab: Conceptualize and execute complex in vitro and in vivo immunology studies including study design, method development, independent data analysis, and technical problem solving. (75% bench work)
Scientific leadership: Assist in goal setting and strategy, project and study planning, resource management, mentorship of junior staff, and hands-on study execution to ensure timely achievement of corporate milestones and goals. Function internally as a key opinion leader in matters related to immunology and tolerance
Supervisor: May manage Research Associate(s) depending on experience including: workflow organization, goal setting, assigning objectives, mentoring, performance evaluation, skills and career development
Collaboration and communication: Work cooperatively with peers and multidisciplinary teams in a highly matrixed lab environment, keep detailed and organized lab records, and present results at team, internal company, and external alliance meetings
Qualification
Required
Ph.D or equivalent in Immunology or a related life science field
1-2 years of biotech/pharma experience. Applicants with relevant postdoctoral experience in immune tolerance and autoimmune diseases will be considered
Broad and deep knowledge in immune response regulation and modulation at the cellular and molecular level
Direct experience in development, troubleshooting, and execution of in vitro immune based assays including primary immune cell culture and differentiation, immune cell phenotyping, and functional assays (e.g., flow cytometry, ELIspot, cytotoxic T cell assays, APC/T cell co-culture) is required
Deep understanding of the antigen presentation process, Treg, DC and/or macrophage biology, and immune modulation
Work authorization in the US is required
Primary immune cell culture of DC, monocyte, macrophage, and T cells including in vitro and ex vivo functional assays
Design and execution of in vivo studies to evaluate therapeutic drug candidates for safety and efficacy in mouse models of autoimmune and inflammatory diseases
Proficiency with comprehensive immune cell phenotyping by multicolor (12+) flow cytometry (Cytek Northern Lights, BD cytometers, CytoFlex), ICC (Cytation), cytokine analyses (CBA, MSD), ELISA, ELISpot, and ICS, and related assays
In vitro and in vivo screening of drug candidates, microplate cell assays, protein expression, cytotoxicity, fluorescent cell and tissue imaging, luminescence, BLI (IVIS), quantitative microscopy and image analysis
Preferred
Knowledge of tolerance, vaccine development and gene therapy/delivery a plus
Preferred experience with molecular biology techniques including characterization of nucleic acid and protein therapeutic payloads
Company
CHEManager International
Wiley’s leading media brand providing first-hand information on the global chemical, life science and process industries
201-500 employees
Funding
Current Stage
Growth StageCompany data provided by crunchbase