Hexagon Bio · 1 day ago
Scientist II / Senior Scientist - Drug Mechanism of Action (MOA)
Menlo Park, CA
Full-time
Onsite
Mid, Senior Level
$140K/yr - $180K/yr
3+ years expHexagon Bio is a drug discovery company focused on developing next-generation antibody–drug conjugates (ADCs) with novel payloads derived from natural products. They are seeking a Scientist II / Senior Scientist to join the Payload Biology team to elucidate the mechanisms of action of novel ADC payloads through the design and execution of biochemical and cell-based assays.
BiotechnologyHealth CareTherapeutics
Responsibilities
Design, develop, and execute cell-based and biochemical assays to elucidate the MOA of novel ADC payload classes
Build mechanistically informative assays that support SAR-driven medicinal chemistry optimization
Investigate payload activity, selectivity, and resistance mechanisms to inform program strategy and downselection
Partner with computational biology colleagues to integrate omics data into MOA and resistance studies
Collaborate closely with ADC, chemistry, protein science, and cell biology teams to ensure assays reflect biologically and therapeutically relevant contexts
Interpret complex datasets and translate results into clear, actionable recommendations for project teams
Present data, conclusions, and strategic insights to cross-functional teams and leadership
Maintain high-quality electronic laboratory notebooks and adhere to safety and best laboratory practices
Contribute to a team culture grounded in scientific rigor, transparency, and collaboration
Qualification
Required
PhD in Biochemistry, Cell Biology, Biophysics, Pharmacology, Chemical Biology, or a related field, with 3–5+ years of post-degree industry experience in biotech or pharma
Demonstrated experience elucidating drug mechanisms of action for small molecules or cytotoxic payloads
Strong hands-on experience with cell-based mechanistic assays relevant to oncology or targeted therapeutics
Knowledge and expertise with flow cytometry
Proven ability to think mechanistically, design creative assays, and solve complex biological problems
Ability to manage multiple priorities and drive projects forward in a fast-paced environment
Strong communication skills and experience influencing cross-functional decision-making
Highly collaborative, proactive, and motivated by scientific discovery and innovation
Preferred
Expertise in developing biochemical assays that generate quantitative, mechanistically interpretable data to guide SAR is a plus
Experience with ADC payloads, cytotoxic agents, or targeted oncology therapies is a strong plus
Benefits
Medical, dental, vision, and voluntary benefits via TriNet
401(k) plan
Support for attending scientific conferences and professional development
Access to Menlo Park Labs amenities, including shuttle service, gym, climbing wall, pool, sports courts, café, bike storage, and EV charging
Team-building events such as Hexagon Happy Hours and company celebrations
Company
Hexagon Bio
Hexagon Bio is a data-driven biotech company developing targeted small molecule therapeutics.
51-200 employees
H1B Sponsorship
Hexagon Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2023 (4)
2022 (1)
Funding
Current Stage
Growth StageTotal Funding
$193.6MKey Investors
Nextech InvestThe Column Group8VC
2022-10-11Series B· $77.3M
2021-09-22Series Unknown· $61M
2020-09-15Series A· $47M
Leadership Team
Maureen Hillenmeyer
Founder and CEO
Recent News
2025-12-19
2025-12-16
2025-12-16
Company data provided by crunchbase