Washington University in St. Louis · 2 days ago
Postdoctoral Research Associate - Genetics
St Louis, MO
Full-time
Onsite
New Grad, Entry LevelWashington University in St. Louis is seeking highly motivated candidates for postdoctoral fellow positions in the Department of Genetics and McDonnell Genome Institute. The fellows will develop research programs in Personalized Medicine focusing on the pathogenic mechanisms of disease-associated variants and will utilize a multi-omics approach to study genetic abnormalities in neurodevelopmental and neurodegenerative disorders.
E-LearningEBooksEducationHigher Education
Responsibilities
Develop research programs in Personalized Medicine aimed at revealing the pathogenic mechanisms of disease-associated variants via monitoring phenotypic changes of genetically perturbed iPSC-derived neurons and glia
Study the mechanistic basis of genetic abnormalities that result in neurodevelopmental, neuropsychiatric, or neurodegenerative disorders, with emphasis on the role of mitochondrial dysfunction and metabolic deficits in disease progression
Use a novel multi-omics approach that integrates high-throughput imaging and machine learning methods with CRISPR/Cas9 screens and saturation mutagenesis to answer central questions about the pathophysiology that results from genetic mutations in mitochondrial proteins, chromatin regulators, and metabolic enzymes
Interpret experiments in the context of curated clinical phenotypes and validate key findings using banked patient samples
Qualification
Required
Ph.D., M.D. Or Equivalent Terminal Or Doctoral Degree
Ability to visit St. Louis for potential interviews
Ability to work in a laboratory environment with potential exposure to biological and chemical hazards
Physically able to wear protective equipment and to provide standard care to research animals
Preferred
Ph.D. or M.D./Ph.D. in biological sciences or related fields
Analytical Thinking
Communication
Genomics
Molecular Biology
Neurodegenerative Diseases
Python (Programming Language)
R Programming
Benefits
Comprehensive and competitive benefits package
Company
Washington University in St. Louis
Washington University’s mission is to discover and disseminate knowledge, and protect the freedom of inquiry through research and teaching.
Founded in 1853
10001+ employees
H1B Sponsorship
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Funding
Current Stage
Late StageTotal Funding
$24.6MKey Investors
National Institute of Allergy and Infectious DiseasesAmerican Academy of Orthopaedic SurgeonsJim McKelvey
2024-09-13Grant
2023-12-01Grant· $0M
2019-01-31Grant
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