Guardant Health · 1 day ago
Senior Data Engineer
Palo Alto, CA
Full-time
Hybrid
Mid, Senior Level
$121K/yr - $166K/yr
5+ years expGuardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. The Senior Data Engineer will design and maintain large-scale data pipelines and develop AI-driven workflows to support analytics and commercial operations.
BiotechnologyHealth CareHealth DiagnosticsOncologyTherapeutics
Responsibilities
Design, build, and maintain large-scale ETL/ELT pipelines using AWS Glue and related AWS services
Develop and optimize data models across Amazon S3, Redshift, and Neptune to support analytics and AI workloads
Implement transformation and data modeling workflows, ensuring data accuracy, consistency, and lineage
Manage data orchestration using Apache Airflow or AWS Step Functions to ensure reliability and timely data delivery
Integrate data from CRM platforms, marketing systems, provider datasets, and operational tools into scalable commercial data pipelines
Build Agentic AI-driven workflows using Agentic AI frameworks such as Langchain, Langgraph, Strands, LLMs and Knowledge Bases
Develop multi-agent systems that support sales enablement, provider insights, and commercial operations automation
Implement retrieval-augmented generation (RAG) pipelines and hybrid search workflows using vector databases and AWS-native retrieval tools
Build and maintain Amazon Neptune knowledge graph
Integrate agent capabilities with internal systems and APIs to support use cases such as provider briefings, objection handling, triage workflows, and content generation
Implement security guardrails and access control for agent tools
Develop evaluation, telemetry, and monitoring processes to assess agent performance, detect hallucinations, and ensure workflow stability
Work closely with Product teams, Commercial Operations, Sales and Marketing, Data Engineering, and to identify automation opportunities
Translate business requirements into scalable technical solutions with high reliability and security
Provide technical leadership and best practices for AI-driven workflow development
Qualification
Required
Bachelor's or Master's degree in Computer Science, Engineering, Data Science, or a related field, or equivalent experience
5+ years of professional experience in data engineering, AI engineering, or related fields
Strong expertise with AWS data engineering technologies, including: AWS Glue, Amazon S3, Amazon Neptune/Redshift, Apache Airflow
Hands-on experience with agentic AI frameworks such as: AWS Strands SDK and Bedrock (highly preferred), Strands SDK, LangGraph, LangChain, CrewAI, or AutoGen
Strong proficiency in Python and experience with distributed data processing frameworks
Practical understanding of LLMs, embeddings, vector search, RAG pipelines, and multi-agent orchestration
Experience building secure, reliable workflow systems with attention to guardrails, error handling, and compliance
Preferred
Experience integrating data from CRM systems (e.g., Salesforce) or other GTM platforms
Experience in commercial operations, sales enablement, healthcare analytics, or diagnostic products
Familiarity with healthcare data compliance, including HIPAA and PHI handling
Experience with Docker, CI/CD pipelines, Kubernetes, or observability tools (CloudWatch, Prometheus, Grafana)
Company
Guardant Health
Guardant Health is a precision oncology company that uses blood tests, data sets, and analytics to provide treatment to cancer patients.
1001-5000 employees
H1B Sponsorship
Guardant Health has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (38)
2024 (50)
2023 (40)
2022 (72)
2021 (57)
2020 (29)
Funding
Current Stage
Public CompanyTotal Funding
$2.53BKey Investors
Baillie GiffordSoftBank Vision FundOrbiMed
2025-11-05Post Ipo Equity· $284.4M
2025-11-05Post Ipo Debt· $350M
2023-12-21Post Ipo Equity· $90.7M
Leadership Team
AmirAli Talasaz
Co-founder and Co-Chief Executive Officer
Helmy Eltoukhy
Chairman and Co-Chief Executive Officer
Recent News
2026-01-03
felicis.com
2025-12-30
Company data provided by crunchbase