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GSK · 1 month ago

Principal Scientist, Discovery DMPK Bioanalytical

Collegeville, PA

Full-time

Onsite

Senior Level, Lead/Staff

5+ years exp

GSK is a global biopharma company focused on uniting science, technology, and talent to get ahead of disease. They are seeking a Principal Scientist to utilize mass spectrometry skills in bioanalytical analysis, supporting discovery programs and driving innovation in large molecule analyses.

BiotechnologyHealth CarePharmaceutical

H1B Sponsor Likely

Responsibilities

Utilize lab-bench technical knowledge and apply experience in LC-MS approaches to support GSK’s portfolio deliverables

Provide key leadership as a subject matter expert in large molecule LC-MS bioanalysis

Plan, develop, and execute on the objective to provide the large molecule LC-MS analyses required by our evolving portfolio

Help define the trajectory of our LC-MS approaches for biologics, collaborating cross-functionally to understand areas of need and delivering to those goals

Establish best practices for sample preparation, quantitation strategies, and data analysis to drive projects forward while building organizational expertise in biopharmaceutical bioanalysis

Qualification

Mass spectrometryLC-MS analysisBioanalytical chemistryHigh resolution mass spectrometryDMPK assaysInstrumentation implementationRegulatory familiarityTroubleshooting skillsOligonucleotide therapeuticsCross-functional leadership

Required

Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 2+ years of postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years

Experience in mass spectrometry -based analysis of biopharmaceutics (e.g., antibodies, antibody-drug conjugates)

Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems

Experience with high resolution mass spectrometry instrumentation and data analysis

Laboratory experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry

Preferred

Proficient in using and troubleshooting Sciex mass spectrometers, including Time-of-Flight instruments

Experience with the bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities)

Prior involvement in matrix leadership, including leading cross-functional initiatives or guiding scientific strategy across multiple teams

Familiarity with regulatory expectations for large molecule bioanalysis

Company

GSK

Glassdoor4.1

We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia

Founded in 1929

London, England, GBR

10001+ employees

http://www.gsk.com

H1B Sponsorship

GSK has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (45)

2024 (56)

2023 (54)

2022 (53)

2021 (54)

2020 (72)

Funding

Current Stage

Public Company

Total Funding

$25.51M

Key Investors

CARB-X

2021-03-02Grant· $18M

2020-09-23Grant· $7.51M

1978-01-13IPO

Leadership Team

Julie Brown

CFO

Mike Elmore

SVP & Chief Information Security Officer, GSK

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