Dovetail Therapeutics · 2 days ago
Senior Scientist, Protein Sciences
Seattle, WA
Full-time
Onsite
Mid, Senior Level
3+ years expDovetail Therapeutics is a Seattle biopharmaceutical company committed to developing novel biotherapeutics. They are seeking a talented and experienced Senior Scientist in Protein Sciences to join their growing R&D team, where the role will involve executing workflows in protein science and antibody discovery.
Biotechnology
Responsibilities
Lead and execute hands-on antibody discovery tasks, including binding domain selection, ELISA-based screening, and DNA sequence analysis
Develop and perform biophysical characterization of antibodies using fit-for-purpose approaches for high-throughput discovery needs
Provide timely support, adapting to project needs in a dynamic environment, supporting both discovery screening and protein characterization as needed
Design and execute experiments and effectively communicate results to a cross-functional team of biologists and protein engineers
Ensure accurate documentation and reporting of experimental results, including sequence-to-function datasets
Work with internal teams and external CROs to coordinate activities and ensure successful execution of deliverables
Qualification
Required
Ph.D. degree in molecular biology, biochemistry or related field with 3+ years of industry experience, or master's degree in molecular biology, biochemistry or related field with 5+ years of industry experience or bachelor's degree in molecular biology, biochemistry or related field with 10+ years of industry experience
Excellent organizational and communication skills with attention to detail
Broad understanding of antibody discovery process, especially as pertains to binding domain generation and selection
Familiarity with discovery screening assays (such as ELISA and other high-throughput assays)
Working knowledge of DNA sequence analysis (Benchling, Geneious, etc.) and basic molecular biology techniques
Expertise in various protein analytical methods including HPLC (SEC, HIC, IEX), CE, DSF, MALS, Western blots, etc
Experience with BLI (Gator or Octet) for affinity measurement, kinetic analysis, and epitope binning
Solid understanding of protein developability assays, including approaches to characterize and optimize candidates for formulation and manufacturing
Familiarity with protein purification techniques using chromatography (SEC, IEX) for lab scale production
Strong critical thinking and the ability to thrive in a fast-paced, team-oriented environment with colleagues from diverse disciplines
Benefits
Medical, dental and vision coverage
Paid parking or transit
A 401(k) plan
Paid time off
Company
Dovetail Therapeutics
Biotechnology company
11-50 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase