Bristol Myers Squibb · 1 day ago
Senior Research Investigator, PBPK
Princeton, NJ
Full-time
Onsite
Mid, Senior Level
$146K/yr - $177K/yr
2+ years expBristol Myers Squibb is a leading biopharmaceutical company focused on transforming patients' lives through science. They are seeking a Senior Research Investigator to provide leadership in developing and applying physiologically based pharmacokinetic (PBPK) models for drug discovery and development, collaborating with multidisciplinary teams to inform clinical development.
BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine
Responsibilities
Provide leadership to and collaboration with multidisciplinary project teams to develop and apply PBPK models
Proficient in the development and application of PBPK models to address drug-discovery and development questions
Partner with external groups to accelerate the internal PBPK efforts in key disease areas
Provide expert support to project teams to design, execute and interpret clinical pharmacology studies with supervision
Leverage existing PBPK tools and analysis packages
With some supervision, network with stakeholders in non-clinical DMPK, biotransformation, and pharmaceutical development to identify and interpret experiments critical for model development and refinement
With some supervision, align PBPK model deliverables with clinical pharmacology, pre-clinical, and clinical development plans as appropriate
Serve as a subject matter expert (SME) to both internal colleagues and the external scientific DMPK, Translational Medicine, Clinical Pharmacology community
Stay informed with emerging literature and science in the DMPK, Translational Medicine, Clinical Pharmacology and PBPK fields
Build and maintain a personal track record of publication in the area of PBPK
Maintain an active relationship with colleagues in TMCP at the project level, as well as in the advancement of Model-Informed Drug Development (MIDD)
Qualification
Required
Ph.D. in DMPK, pharmaceutics, clinical pharmacology, engineering, toxicology or a related field
M.S. in appropriate field with significantly more experience may be considered
2+ years of pharmaceutical industry experience in applying PBPK modeling for DDI and PK predictions
Excellent understanding of the theory and principles in pharmacokinetics and pharmacodynamics, drug disposition of small molecules and therapeutic proteins
Understanding of the theory, principles and statistical aspects of mathematical modeling and simulation
Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop PBPK models for small molecules, therapeutic proteins, and new modalities
Ability to communicate internally and externally on topics related to translational medicine, clinical pharmacology and PBPK is required
Hands-on experience with one or more of the modeling software like Simcyp, GastroPlus, PKSim, etc
Preferred
Hands-on experience with general programming and data analysis tools/languages such as R, Matlab, Julia, etc, is desirable
Desire to interact as a modeling and simulation expert with matrix project teams working closely with experts from different functional areas (pre-clinical and clinical)
Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as translational medicine, and clinical pharmacology
Benefits
Health Coverage Medical, pharmacy, dental, and vision care.
Wellbeing Support Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off
US Exempt Employees flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Eligibility Disclosure The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work.
Company
Bristol Myers Squibb
At Bristol Myers Squibb, we work every day to transform patients’ lives through science.
10001+ employees
H1B Sponsorship
Bristol Myers Squibb has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (247)
2024 (278)
2023 (231)
2022 (180)
2021 (181)
2020 (169)
Funding
Current Stage
Public CompanyTotal Funding
$29.32BKey Investors
Venrock
2025-11-05Post Ipo Debt· $5.74B
2024-02-14Post Ipo Debt· $13B
2023-10-30Post Ipo Debt· $4.5B
Leadership Team
Charles Bancroft
CFO
Cristian Massacesi
Executive Vice President, Chief Medical Officer and Head of Development
Recent News
2026-01-07
2026-01-07
2026-01-07
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