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Flagship Pioneering · 1 day ago

Principal Scientist, Analytical Development

Cambridge, MA USA

Full-time

Onsite

Lead/Staff

$163K/yr - $214K/yr

8+ years exp

Mirai Bio, Inc is a Flagship backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics. They are seeking a highly experienced and innovative Principal Scientist to lead analytical development activities focused on novel lipid nanoparticles and nucleic acid cargos for therapeutics and vaccines.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Lead analytical method development and testing for characterization of LNP-based drug products and nucleic acid drug substances (incl. RNA, DNA)

Oversee analytical team to provide broad testing support across R&D functions using platform methods including lipid and nucleic acid composition, integrity, purity, particle size, encapsulation, and more. On-site presence and active hands-on involvement in experimental work is expected

Design and execute complex experiments for in-depth characterization using DLS, HPLC, LC-MS, SEC, FFF/SEC-MALS, CE, UV-Vis, NMR, Cryo-EM and other advanced techniques for nanoparticle characterization

Collaborate with Formulation, Process Development, and Translational teams to support batch testing, stability characterization, optimization, and troubleshooting. Contribute to establishing acceptable ranges for critical quality attributes (CQAs) and parameters (CPPs)

Manage/establish methods at external labs / CROs to complement internal capability

Ensure lab instruments are in working condition, manage instrument vendors, and organize demonstrations of new equipment

Prepare and review documentation including certificates of analysis, method protocols, laboratory notebooks, and reports

Stay current with emerging analytical technologies and industry trends in LNP-based delivery systems, including targeted LNPs

Supervise and mentor junior scientists and foster a culture of scientific and operational excellence

Qualification

Analytical ChemistryLipid Nanoparticle CharacterizationNucleic Acid CharacterizationHPLCBiophysical MethodsLeadership SkillsProblem-Solving SkillsCDMOsMolecular BiologyGMP AwarenessCommunication Skills

Required

Ph.D. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related discipline with 8+ years of relevant industry experience; or M.S. with 10+ years

Demonstrated expertise with analytical methods for lipid nanoparticle characterization, including biochemical / biophysical methods

Experience with characterization of nucleic acid-based therapeutics (mRNA, siRNA, DNA)

Experience with characterization of proteins, mAbs, antibody fragments, and peptides

Hands-on experience with techniques including HPLC, DLS, NTA, CE, LC-MS/MS, UV-Vis spectroscopy, and single-particle characterization methods

Excellent problem-solving, communication, and leadership skills

Prior experience in a supervisory role

Preferred

Experience working with external labs and/or CDMOs in a matrixed development environment

Prior involvement in early stage development and IND filings, preferably for genetic medicines

Familiarity with stability studies, forced degradation, and comparability assessments

Familiarity with molecular biology and bioconjugation techniques

Awareness of ICH guidelines, GMP, and regulatory expectations for analytical method validation and CMC submissions

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)