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Beacon Hill · 1 day ago

Sr. Research Scientist Biophysics

South San Francisco, CA

Full-time

Onsite

Mid, Senior Level

3+ years exp

Beacon Hill is seeking a highly motivated and skilled Biophysicist with hands-on experience in small molecule drug discovery to join their dynamic Lead Discovery group. The role involves biophysical and mechanistic characterization of small-molecule ligands binding to protein targets, supporting compound profiling and advancing the drug discovery pipeline.

Staffing Agency

H1B Sponsor Likely

Responsibilities

Independently design, execute, and interpret binding characterization studies using SPR (Biacore S200 and 8K+)

Perform routine compound screening and advanced mechanistic analyses using biophysical platforms such as nanoDSF, DLS, and Spectral Shift assays

Support assay development and implementation of new instrumentation in collaboration with the Principal Scientist

Serve as the primary point of contact for CRO partners conducting externalized biophysical studies

Coordinate timelines, assay execution, data delivery, and troubleshooting with external collaborators

Maintain detailed experimental records and perform high-quality data analysis to drive SAR and support hit-to-lead and lead optimization activities

Present findings in internal team meetings and prepare industry-standard study reports

Work closely with Pharmacology and Medicinal Chemistry teams, sharing data and insights in weekly or bi-weekly project meetings

Contribute to a collaborative, fast-paced research environment aligned with company values and scientific rigor

Qualification

SPR assay designSmall molecule drug discoveryBiophysical methodsData analysisGraphing softwareTroubleshooting skillsCommunication skills

Required

PhD in Biophysics, Biochemistry, or a related discipline

3+ years of industry or relevant academic experience in small molecule drug discovery biophysics

Demonstrated expertise in SPR assay design, execution, and interpretation for small molecule–protein interactions

Strong theoretical and technical background in additional biophysical methods (e.g., TSA, DLS, Spectral Shift, NMR, ITC)

Ability to independently design experiments, analyze data, and determine optimal assay strategies

Excellent troubleshooting, organizational, and planning skills

Strong written and verbal communication abilities

Preferred

Experience with graphing/statistical software (e.g., GraphPad Prism) is a plus

Company

Beacon Hill

Glassdoor3.9

Beacon Hill was founded to set a new standard in search, career placement and flexible staffing.

Founded in 2000

Boston, Massachusetts, USA

1001-5000 employees

http://www.beaconhillstaffing.com

H1B Sponsorship

Beacon Hill has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (38)

2024 (94)

2023 (76)

2022 (60)

2021 (77)

2020 (86)