Prolaio · 1 day ago
Chief Data & Analytics Officer (CDAO)
Chicago, IL
Full-time
Onsite
Director/Executive
15+ years expProlaio is a company focused on transforming heart care through innovative data solutions. They are seeking a Chief Data & Analytics Officer (CDAO) to lead the development of their Cardiac Intelligence platform, responsible for turning patient data into actionable insights to improve clinical outcomes and operational efficiency.
AnalyticsHealth CareMedical
Responsibilities
Define and execute the enterprise data strategy, treating data as a product that drives value for Prolaio’s remote monitoring platform and Kardigan’s therapeutic development
Establish a robust data governance framework to ensure data quality, integrity, and traceability across the entire lifecycle, ensuring readiness for FDA regulatory submissions (21 CFR Part 11)
Champion a "data-first" culture by promoting data literacy across clinical, operational, and commercial teams, aligning technical roadmaps with business objectives
Lead the deployment of Large Language Models (LLMs) and Generative AI to automate protocol design, extract insights from unstructured clinical notes, and streamline regulatory documentation drafting
Oversee the implementation of Retrieval-Augmented Generation (RAG) architectures to securely query internal knowledge bases and scientific literature without hallucination risks
Develop "Agentic AI" workflows to enhance patient engagement and automate routine clinical operations tasks, while maintaining "human-in-the-loop" oversight for safety
Direct the R&D of novel digital biomarkers derived from wearable sensor data (ECG, PPG, accelerometry), utilizing advanced signal processing and deep learning techniques
Partner with the Chief Medical Officer to design validation studies that demonstrate the clinical utility of digital endpoints for use in regulatory decision-making
Drive the "Cardiac Intelligence" agenda by integrating multimodal data (genomic, phenotypic, and sensor-based) to refine patient stratification for precision cardiology
Leverage Electronic Medical Records (EMR) and Claims data to construct synthetic control arms, optimize patient recruitment, and conduct long-term post-market surveillance
Implement predictive analytics for clinical operations, optimizing site selection and forecasting enrollment to minimize trial delays and costs
Manage the ingestion and harmonization of diverse Real-World Data (RWD) sources into a unified Common Data Model (CDM) to support cross-functional analysis
Recruit, retain, and develop a best-in-class team of data scientists, ML engineers, and biostatisticians, fostering an environment of innovation and scientific rigor
Collaborate closely with the CIO to ensure data infrastructure (cloud compute, storage) meets the demanding requirements of AI training and high-frequency sensor data analysis
Partner with the VP of Supply Chain to leverage data for inventory optimization and logistics forecasting
Qualification
Required
Ph.D. or Master's degree in Data Science, Bioinformatics, Computer Science, Statistics, or a related quantitative field
15+ years of progressive leadership experience in data science or analytics, with at least 5 years in the life sciences, biotech, or pharmaceutical industry
Proven track record of deploying Large Language Models (LLMs) and Generative AI solutions in a regulated enterprise environment (experience with RAG and prompt engineering preferred)
Deep expertise in developing and validating digital biomarkers or clinical endpoints using sensor data and time-series analysis
Strong working knowledge of Real-World Data ecosystems (EMR, Claims, Registry data) and experience with clinical data standards (CDISC, OMOP, FHIR)
Demonstrated experience in clinical trial operations, including protocol optimization and patient recruitment strategies
Experience in Regulatory and Quality Management Systems including documenting and managing design history files and supporting and building regulatory submissions
Executive presence with the ability to translate complex technical concepts into strategic business value for the Prolaio Leadership Team, Kardigan Executive Committee and Board of Directors
Comprehensive understanding of data privacy and regulatory compliance (GDPR, CCPA, HIPAA, FDA Software as a Medical Device guidelines)
Experience leading and growing a team of experienced professionals
Benefits
Medical, dental, and vision plans with multiple options and strong company contributions.
HSA, FSA, commuter benefits, and a $1,200 annual Lifestyle Spending Account to support wellness, commuting, family needs, and more.
Generous paid time off, sick leave, and company holidays.
Paid parental leave, caregiver leave, and support for growing families.
Company-paid life insurance and short- and long-term disability coverage.
401(k) plan to help you build long-term financial security.
Easy access to telehealth and optional supplemental coverage for life’s unexpected moments.
Company
Prolaio
Prolaio is a HealthTech company that focuses on prescriptive analytics.
51-200 employees
H1B Sponsorship
Prolaio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (2)
Funding
Current Stage
Growth StageTotal Funding
$25.5M2025-03-27Acquired
2023-07-26Series Unknown· $25.5M
Recent News
2025-10-03
Company data provided by crunchbase