AccuraGen · 1 day ago
Senior Staff Bioinformatics Scientist
San Jose, CA
Full-time
Onsite
Senior Level, Lead/StaffAccuraGen is a company focused on advancing genomic technologies, and they are seeking a Senior Staff Bioinformatics Scientist to lead the development of statistical and algorithmic methods for NGS-based variant detection. This role requires collaboration with various teams to create robust analytical pipelines and improve variant-calling algorithms.
BiotechnologyHealth CareMedical Device
Responsibilities
Improve and extend somatic variant-calling algorithms for tumor tissue and cfDNA-based mutation detection
Develop, validate, and refine MRD-calling algorithms with an emphasis on sensitivity, specificity, and robustness
Design and implement benchmarking, evaluation, and quality control (QC) methodologies
Lead troubleshooting efforts, including root-cause analysis of analytical or pipeline failures, and drive corrective actions
Implement algorithms in production-quality code and collaborate with engineering teams to integrate methods into scalable pipelines and workflows
Partner with assay development teams on new technologies and assay iterations requiring customized analysis strategies and algorithm development
Document analytical methods, validation results, and design decisions; clearly communicate findings, limitations, and trade-offs to technical and cross-functional stakeholders
Qualification
Required
Ph.D. in Statistics, Biostatistics, Computer Science, Bioinformatics, Computational Biology, Applied Mathematics, or a related field, with relevant postdoctoral or industry experience
Strong foundation in statistical inference and modeling, including uncertainty quantification and decision thresholding
Prior experience working with genomics data, including WGS or large-scale NGS datasets, and a solid understanding of technical and biological noise sources
Demonstrated software implementation skills in Python and/or a performance-oriented language (e.g., C++, Rust, Java), with experience writing maintainable, testable, production-quality code
Familiarity with standard genomics data formats and tooling (e.g., FASTQ, BAM/CRAM, VCF) and common processing workflows
Experience working in regulated product development environments (e.g., FDA, IVD), including documentation practices, analytical validation, and design controls
Excellent communication and collaboration skills, with the ability to work effectively across research, engineering, and assay development teams
Preferred
Hands-on experience with cfDNA analysis and/or MRD detection, including ultra-low-frequency variant calling and/or epigenetics-based analyses
Machine learning experience, particularly in settings involving class imbalance, model evaluation, calibration, and decision optimization
Experience collaborating closely with assay development teams on experimental design, data analysis planning, and iterative assay optimization
Benefits
Health Care Plan (Medical, Dental & Vision)
Retirement Plan (401k, IRA)
Paid Time Off (Vacation, Sick & Public Holidays)
Company
AccuraGen
Since its inception in 2013, AccuraGen has pioneered the development of liquid biopsy technology to facilitate more personalized cancer treatment.
Founded in 2013
11-50 employees
H1B Sponsorship
AccuraGen has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2023 (1)
2020 (1)
Funding
Current Stage
Growth StageTotal Funding
$40M2016-06-01Series B· $40M
2013-05-26Series A
Leadership Team
Li Weng
SVP of R&D
Malek Faham
Chief Scientific Officer
Company data provided by crunchbase