Prime Medicine, Inc. · 1 day ago
Senior Associate Engineer II, Supply Chain & External Manufacturing
Watertown, MA
Contract
Onsite
Mid, Senior Level
$94K/yr - $115K/yr
4+ years expPrime Medicine is a leading biotechnology company focused on gene editing therapies. The Senior Associate Engineer II will manage external partnerships and support non-clinical development and CMC/manufacturing, ensuring alignment between internal teams and external partners.
BiotechnologyGeneticsLife ScienceMedicalTherapeutics
Responsibilities
Serve as the primary point of contact and project manager for assigned CDMO, CTL, CRO and other external partners across both non-clinical and CMC projects and activities. The position will be responsible for coordinating communications between Prime technical experts and external partners, prioritizing and facilitating external project team meetings
Establish and run effective meetings with partners and ensure timely communication and resolution of issues
Coordinate with logistics providers and partners on shipment of materials, intermediates, and finished products between Prime and external sites ensuring compliance with relevant shipping and regulatory requirements (permits, customs, chain of custody, temperature control)
Build strong, trust-based relationships and drive continuous improvement in performance and ways of working
Collaborate with stakeholders in Non-Clinical Development, CMC/Manufacturing and Quality, Program Management, Finance, Legal and others to align on objectives, expectations and priorities for external work
Translate program strategies into clear, actionable SOWs/SOCs with defined deliverables, timelines, and roles/responsibilities
Collaborate with Legal, Finance, Procurement and technical SMEs on MSAs, Quality/Technical Agreements, SOWs/SOCs and amendments
Own the operational aspects of SOW/SOC and change-order management
Support budget tracking and financial planning for assigned vendors (forecasts, accrual inputs, and cost/risk trade-offs)
Keep internal and external teams aligned as plans evolve with clear and concise documentation, as well as facilitating cross-functional meetings focused on execution and decision-making
Develop and maintain integrated project plans for external workstreams aligned with overall program timelines and decision points
Monitor progress against milestones and KPIs and drive accountability to keep work on track
Develop and use dashboards and reporting to improve visibility into vendor performance, contract status, risks and key milestones
Proactively identify risks and dependencies, propose mitigation options, and maintain risk/issue/action logs
Embrace the use of AI and other digital tools to streamline workflows, improve decision-making, and accelerate execution
Use LEAN and Six Sigma methodologies to develop and improve business processes
Additional duties as assigned
Qualification
Required
BS/MS degree in Life Sciences, Chemistry, Engineering, Supply Chain, Business or related discipline; a background in STEM is preferred
4 - 6+ years of relevant industrial experience in biotechnology, pharmaceuticals, or cell and gene therapy, with significant exposure to non-clinical development and/or CMC/manufacturing
Direct experience managing external partners (e.g., CDMOs, CTLs, CROs), including project execution, relationship management, and issue resolution
Demonstrated experience with contracts, SOWs/SOCs and change orders, working closely with Legal, Finance and technical teams
Strong project management skills including planning, prioritization, tracking, and cross-functional coordination in a fast-paced, evolving environment
Fluent in the use of digital and AI-based tools to manage projects, data and documentation, with an interest in learning and experimenting with new tools as they evolve
A hands-on, 'just roll up the sleeves' mindset that keeps programs and partnerships moving forward
Excellent verbal and written communication skills; able to influence and align diverse stakeholders without formal authority
Preferred
Familiarity with GxP environments and advanced therapy modalities (e.g., CGT) is strongly preferred
Benefits
Medical
Dental
Vision
Life insurance
A 401(k) match
Equity programs
Generous paid time off
Wellness days
Company-wide recharge breaks
Company
Prime Medicine, Inc.
Prime Medicine was founded to bring the promise of gene editing to patients.
201-500 employees
H1B Sponsorship
Prime Medicine, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (7)
2024 (12)
2023 (11)
2022 (5)
2021 (5)
Funding
Current Stage
Public CompanyTotal Funding
$558.15MKey Investors
Google VenturesCystic Fibrosis FoundationBristol-Myers Squibb
2025-08-01Post Ipo Equity· $4.95M
2025-07-30Post Ipo Equity· $144.2M
2025-07-16Post Ipo Equity· $24M
Leadership Team
Allan Reine
Chief Executive Officer and Board Member
Andrew Anzalone
Director, Head of Prime Editing Platform
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