Astellas Pharma · 1 week ago
Scientist I, Antibody Engineering
South San Francisco, CA
Full-time
Onsite
New Grad, Entry Level
$91K/yr - $143K/yr
0+ years expAstellas Pharma is a pharmaceutical company focused on developing innovative therapies for patients. The Scientist I, Antibody Engineering role is responsible for leading antibody and protein production, performing purification and characterization of biologics, and coordinating production activities with stakeholders.
BiotechnologyHealth CareMedical
Responsibilities
Lead antibody and protein production by performing purification of mAbs, bi-/multi-specific antibodies, and Fc fusion proteins at various scales using CHO and 293 cell lines
Perform QC and characterize recombinant antibodies and proteins from both internal and external sources; summarize results and present to project teams
Act as a technical lead for maintaining priority work and troubleshooting production issues
Plan and coordinate internal and external production activities and communicate with key stakeholders regularly
Qualification
Required
PhD with 0-2 years, MS with 4+ years, or BS with 6+ years of related experience in protein sciences team
Extensive experience in purification of mAbs, bi-/multi-specific antibodies, and Fc-fusion proteins using AKTA FPLC by protein A/G, IMAC, HIC, IEX, SEC chromatography methods
Experience in protein characterization techniques, such as analytical SEC, HIC, cIEF, CE-SDS/SDS-PAGE, DSF, and endotoxin testing
Demonstrated ability to conceive and design experiments, develop and optimize protocols/assays, and interpret experimental results
Demonstrated ability to work independently with minimal supervision and ability to effectively collaborate with other teams; collegiality is a critical attribute
Diligence and meticulous attention to detail in experimentation and ELN record keeping
Strong work ethic, good team player, willingness to fill gaps, demonstrated flexibility/adaptability to meet critical research related timelines
Collaborative mindset to work with global team members
Preferred
Proficiencies in molecular biology techniques, including DNA construct design, PCR, DNA purification and molecular cloning
Prior experience in SPR/BLI and/or mass spectrometry
Knowledge of conditional activation: e.g. masking technologies, tumor-specific activation or payload delivery
Benefits
Medical, Dental and Vision Insurance
Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
401(k) match and annual company contribution
Company paid life insurance
Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
Long Term Incentive Plan for eligible positions
Company-paid fleet vehicle for eligible positions
Referral bonus program
Company
Astellas Pharma
Astellas Pharma is a global pharmaceutical research & development company.
10001+ employees
H1B Sponsorship
Astellas Pharma has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (7)
2024 (4)
2023 (4)
2022 (2)
2021 (3)
2020 (5)
Funding
Current Stage
Public CompanyTotal Funding
unknownKey Investors
National Institute on Drug Abuse (NIDA)
2020-07-22Grant
2008-10-13IPO
Leadership Team
Amanda Hart
Head, Global Commercial Analytics and Reporting
Recent News
2026-01-07
Company data provided by crunchbase