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EMD Serono, Inc. · 1 day ago

Scientist - Neuroscience & Immunology

Billerica, MA

Full-time

Onsite

Entry, Mid Level

$84K/yr - $135K/yr

1+ years exp

EMD Serono is a global healthcare company dedicated to improving lives through innovative science and technology. The Scientist will contribute to drug discovery for neurodegenerative and autoimmune diseases by executing in vitro cell-based assays and collaborating with an international team of scientists.

BiotechnologyHealth CareHealth Diagnostics

Work & Life Balance

No H1B

Responsibilities

Plan, execute, and lead in vitro studies using human iPSC-derived cell types, or cell lines to support target validation and drug candidate evaluation efforts

Conduct translational biomarker discovery using patient samples or disease-relevant cell-based assays to support pharmacodynamics and target engagement biomarker discovery

Operate a variety of laboratory equipment, including microscopes/automated imagers, flow cytometers, qPCR machines, and spectrophotometers

Record data accurately in the Electronic Laboratory Notebook and maintain records per company policy and legal requirements

Prepare data reports and presentations to lab heads, project teams, and at external meetings

Independently design, execute, analyze, interpret, and troubleshoot experiments to support pipeline progression

Provide technical support to colleagues in own area of expertise when necessary

Work closely with members in RU-N&I to support departmental goals

Qualification

Human iPSC-derived modelsMammalian cell cultureTransfection techniquesDrug discovery experienceLive-cell imagingGene expression analysisBioanalytical assaysResearch analytical softwareCuriosityEnthusiasmCommunication skillsTeam collaborationSelf-motivated

Required

Master's degree in Biology, Neurobiology, Immunology or other Science discipline with 2+ years of laboratory experience in Academia, Pharma, Biotech or CRO

OR PhD in Biology, Neurobiology, Immunology, or other Science discipline with 1+ years of laboratory experience in Academia, Pharma, Biotech or CRO

Preferred

Demonstrated experience with human iPSC-derived neural disease models

Knowledge and hands-on experience in the following areas: Maintaining mammalian cell culture, Primary neurons or glia, Co-culture and triculture systems, PBMCs

Transfection of cells to introduce siRNAs, ASO, or CRISPR-based gene editing tools to suppress or knockout specific genes

Live-cell imaging and imaging analysis experience using an Incucyte or similar automated imager

Immunocytochemistry and/or RNAscope

Gene expression and protein analyses: DNA/RNA isolation, qPCR platforms (Applied biosystems QuantStudio, Nanostring, etc.), western blotting (SallySue, Wes)

Bioanalytical assays: AlphaLISA, Meso Scale Discovery (MSD)

Pharmaceutical industry/ Drug discovery experience

Experience on a pipeline project team

Proficient with research analytical software: GraphPad Prism, Microsoft Office, FIJI (or other image analysis software), QuantStudio

Demonstrated ability to work independently in a self-motivated, pro-active manner

Comfortable with designing and executing experiments based on protocols provided by literature, seminars, and/or other scientists

Good understanding of basic drug discovery principles

Enthusiasm, curiosity, and passion for exploring new biology with relevance to human disease

Desire, demonstration of ownership, accountability, and ability to work efficiently in a fast-paced, high functioning cross-functional team

Excellent interpersonal and written communication skills