FIG Therapeutics, Inc. · 1 day ago
Senior Scientist (In Vivo Immuno Oncology)
Valhalla, NY
Full-time
Onsite
Mid, Senior Level
$75K/yr - $110K/yrFIG Therapeutics, Inc. is a preclinical stage biotech company developing innovative gene immunotherapy solutions. They are seeking a hands-on In-Vivo Scientist to lead and execute preclinical studies and assays to support IND filing, requiring expertise in PDX models and tumor immunotherapy research.
Biotechnology
No H1B
Responsibilities
Design, optimize, and run in-vitro potency & functional assays for multi-domain immune effectors
Develop and validate quantitative assays: RT-qPCR, digital PCR (dPCR), ELISA, Luminex multiplex cytokine panels, ELISPOT, Western blot
Build, optimize and analyze multicolor flow cytometry panels (immunophenotyping, T-cell activation, exhaustion markers, Treg analysis) and perform associated data analysis (FlowJo/Cytobank/others)
Run in-vitro immune function assays: PBMC cytotoxicity, NK/ADCC, DC activation, antigen-presentation readouts
Establish and run TME models: 2D, 3D spheroids/organoids, tumor:immune co-cultures; provide assay qualification (precision, accuracy, dynamic range)
Lead in vivo programs: generation and management of CD34⁺ humanized mice, engraftment of patient-derived prostate xenografts (PDX), tumor implantation, intratumoral injection dosing, surgical resection, necropsy, tissue processing for flow/IHC/IF and molecular readouts
Design and execute GLP-style biodistribution, PK/PD, and toxicology study plans in collaboration with CROs; write and review study protocols and reports for IND packages
Author SOPs, experimental design docs, technical reports, and contribute to IND-enabling documentation
Maintain rigorous data integrity, sample tracking, and reagent QC; assist with reagent sourcing, vendor qualification and basic CMC input
Mentor and coordinate work with any junior scientists/technicians and external CRO teams
Qualification
Required
PhD in a related field (i.e. immunology or oncology)
Proven track record in solid tumor immunotherapy research in humanized CD34+ mouse models (CDX and PDX)
Direct experience with PDX tumor models (prostate)
Intratumoral injection and in vivo transfection optimization
Surgical tumor resection/necropsy with downstream tissue processing/analysis (IHC/IF and flow cytometry)
Cell culture and transfection/transduction of primary tumor cells, T cells, and cancer cell lines
Development of cancer and immune cell co-culture assays
Establishment of 3D organoid models of solid tumor TME
Assay development for multicolor flow cytometry panels, ELISA, Luminex, ELISPOT, RT-qPCR, and digital PCR (dPCR)
Proven ability to independently design experiments, troubleshoot complex failures, and author SOPs and study reports used to inform CRO/IND decisions
Experience coordinating with CROs on GLP-style biodistribution/toxicity/TK studies and contributing to study plans
Previous track record of IND support (authoring preclinical sections) and interactions with regulatory consultants
Applicants must be authorized to work in the United States without sponsorship
Must have performed each item in the 'Must-Have' qualifications list within the last 18 months
Preferred
Experience with intratumoral delivery
Hands-on generation of CD34⁺ humanized mice
Expertise in rational design of lipid nanoparticles for plasmid DNA delivery
Viral vector (adenovirus and HSV), RNA, and polycistronic DNA plasmid design
Benefits
Health insurance
Dental
Vision
Company
FIG Therapeutics, Inc.
FIG (Factor Induced Gene) Therapeutics is a biotech developing a proprietary intratumorally delivered gene immunotherapy that harnesses cancer-causing machinery to drive a multimodal immunotherapy that inhibits more immune evasion mechanisms than anything before.
2-10 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase