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Nurix · 1 day ago

Associate Director, Clinical Pharmacology

Brisbane, CA

Full-time

Onsite

Lead/Staff, Director/Executive

$208K/yr - $240K/yr

8+ years exp

Nurix Therapeutics is a biopharmaceutical company focused on the discovery and development of small molecule therapies for cancer and immune disorders. The Associate Director in the Clinical Pharmacology group will lead pharmacometric efforts, develop PK/PD modeling, and collaborate across functions to advance drug discovery and development.

Artificial Intelligence (AI)Data IntegrationGenerative AI

Responsibilities

Utilize quantitative approaches to impact model-informed drug discovery and development in areas such as human dose projections, dose regimen identification and optimization

Lead and conduct pharmacometric workstreams such as but not limited to noncompartmental analyses, exposure-response analyses, population PK/PD modeling, PBPK modeling and QSP modeling, and running model-based simulations

Conduct exploratory modeling activities to support decision-making and clinical strategy

Collaborate across functions within the company and oversee contract vendors to advance pharmacometric efforts and activities

Oversee and contribute to clinical pharmacology sections of clinical study protocols, SAPs, CSRs, stand-alone PK/PD reports, Clinical development plans

Author and review clinical pharmacology documents for submission and/or response to regulatory agencies

Actively identify state-of-the-art quantitative approaches in the field for potential applications to projects, including the use of artificial intelligence/machine learning (AI/ML) techniques

Qualification

PharmacometricsPK/PD modelingPBPK modelingQSP modelingModelingSimulationData analysisClinical pharmacology documentsSoftware proficiencyOral communicationWritten communicationProblem-solvingEmotional intelligenceTeam-oriented

Required

PharmD or PhD or MS in a field related to Pharmacometrics with 8+ years of industry or similar experience in Pharmacometrics, Clinical Pharmacology or Quantitative Systems Pharmacology

Extensive hands-on experience in using modeling and simulation techniques in pharmaceutical development, such as population PK/PD modeling, PBPK modeling or QSP modeling

Exceptional oral and written communication skills and excellent problem-solving skills

Previous experience in authoring and reviewing clinical pharmacology documents for submission and/or response to regulatory agencies

Demonstrated past performance of functioning efficiently in a dynamic, cooperative, team-oriented environment showcasing emotional intelligence (respect and empathy)

High proficiency in using common software and data analysis packages (e.g., R, WinNonlin, Simcyp, GastroPlus, Monolix, NONMEM)