Treeline · 4 weeks ago
Senior Scientist, Mass Spectrometry Technologies
San Diego, CA
Full-time
Onsite
Mid, Senior Level
$152K/yr - $174K/yr
4+ years expTreeline Biosciences is an innovative biotechnology company focused on developing new medicines against challenging targets in cancer and other life-threatening diseases. They are seeking a Senior Scientist to join their Mass Spectrometry Technologies group in San Diego, CA, responsible for delivering high-quality scientific data and driving small molecule drug discovery through the application and development of proteomics approaches.
BiotechnologyHealth CareLife ScienceMedicalPrecision Medicine
Responsibilities
Application and co-development of various quantitative LC-MS2 proteomics assays (DDA, DIA, PRM, TMT) to support ligand-treated biological samples
Proficient with sample preparation (TMT-labeling and affinity enrichment) and MS data interpretation (Skyline, Proteome Discoverer, Sequest)
Highly capable of independently operating and maintaining LC-MS systems (Thermo-Ascend, Thermo-Lumos.)
Key contributor within Mass Spec Technologies team, supporting our capability to provide both routine and advanced MS qualitative and quantitative data to support multiple drug programs
Collaborate with other members of the Lead Discovery team (protein sciences, biophysics, biochemistry, structural biology) to characterize protein targets through small molecule ligand binding assays
Work with Treeline Lab Operations staff and external vendors to ensure smooth laboratory operations
Qualification
Required
Ph.D. degree plus 4+ years focused mass spectrometry experience in a scientific or technical field, and demonstrated lab hands-on experience
At least 2 years of drug discovery experience in biotech or pharma
Experience maintaining and operating mass spectrometry instrumentation
Familiarity with mass spectrometry software (e.g., MassHunter XCalibur, Skyline, Proteome Discoverer)
Expertise in common wetlab techniques: protein assays, small molecule screens, etc
Ability to work efficiently and deliver detailed results within defined timelines and to collaborate in a multidisciplinary team
Preferred
Experience analyzing and organizing data with R, Python is a highly desirable
Familiarity with biophysical methods (SPR, DSF, MST), or biochemistry is a plus
Company
Treeline
Treeline (or Treeline Biosciences) is a privately held, clinical-stage biopharma company that aspires to make medicines at the highest level.
51-200 employees
H1B Sponsorship
Treeline has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (4)
2023 (3)
2021 (1)
Funding
Current Stage
Growth StageTotal Funding
$1.09BKey Investors
AI Life Sciences Investments LLCKohlberg Kravis Roberts
2025-09-03Series A· $200M
2024-10-17Undisclosed· $421M
2022-10-11Series A· $261.27M
Leadership Team
Spencer Smith
Chief Financial Officer
Recent News
2025-10-04
2025-10-01
Genetic Engineering News
2025-09-30
Company data provided by crunchbase