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AstraZeneca · 1 day ago

Scientist - Conjugation and Purification

US - Gaithersburg - MD

Full-time

Onsite

Mid Level

$87K/yr - $131K/yr

3+ years exp

AstraZeneca is embarking on an exciting new frontier in medical science with their Aging Research Group, focusing on developing innovative therapeutics. The Scientist in Conjugation and Purification will be responsible for innovating and generating high-quality antibody drug conjugates across various therapeutic areas, contributing to multi-disciplinary drug development efforts.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Conjugation, purification and characterization of precursors for radio-conjugates (RC) and ADC using multiple validated methodologies

Development and optimization of novel conjugation methodologies to improve RC and ADC properties

Radiolabeling of RC for in vitro and biodistribution evaluations

Collaborate and work with a diverse group of scientists across multiple therapeutic areas, chemistry, and process development to ensure timely progress in research projects and drive technological innovations

Partner with colleagues on laboratory maintenance, including maintenance of equipment and lab safety

Qualification

Protein purificationChromatography techniquesAnalytical techniquesRadiochemistry experienceProblem-solving mindsetCommunication skills

Required

Bachelor's or Master's degree in biotechnology, Pharmaceuticals Sciences, Chemical Biology, Biochemistry, Chemistry, or other relevant scientific field with 3+ years (BS degree) or 0-1 years (MS degree) of relevant experience

Hands-on experience and knowledge of protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC preferred

Working knowledge of characterization using analytical techniques like Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, etc

Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines

Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset and maintains a detailed laboratory notebook

Preferred

Demonstrated hands-on experience in the generation of RC and ADC

Experience with radiochemistry and related assays

Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management

Benefits

Short-term incentive bonuses

Equity-based awards for salaried roles

Commissions for sales roles

Qualified retirement programs

Paid time off (i.e., vacation, holiday, and leaves)

Health, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2021 (2)

2020 (11)