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Guidehouse · 21 hours ago

Research Scientist

Bethesda, MD

Full-time

Onsite

Mid, Senior Level

$85K/yr - $141K/yr

4+ years exp

Guidehouse is currently searching for a Research Scientist to provide support services to satisfy the overall operational objectives within the National Institutes of Health. This role involves optimizing protocols for stem cell differentiation and conducting experiments to enhance the efficacy of hematopoietic stem cells.

AdviceConsultingManagement Consulting

No H1B

Security Clearance Required

Responsibilities

Continuously optimize and implement protocols to enhance the differentiation of human induced pluripotent stem cells (iPSCs) into engraftable hematopoietic stem cells (HSCs)

Conduct experiments to ectopically activate master transcription factors that are crucial for directing cell lineage determination, ensuring that the iPSCs differentiate into the desired cell type

Investigate and apply inhibitors of key epigenetic regulators during the early stages of differentiation to enhance the developmental pathway towards HSCs

Optimize the ectopic expression of homing receptors, with a focus on the CXCR4 chemokine receptor, to improve the homing efficiency and survival of HSCs post-transplantation

Analyze experimental data, maintain detailed records of experiments, and prepare reports or presentations summarizing findings and progress in refining the differentiation platform

Work collaboratively with other researchers and team members to integrate findings and refine strategies, ensuring alignment with overall research goals

Contribute to the identification of learning needs for the CMTB environment and provide learning opportunities for others

Recommend and implement approaches and solutions to problems that may arise

Collaborate with experts to analyze and report data as applicable

Draft manuscripts for publication in scientific journals

Present findings at scientific meetings

Qualification

Ph.D.M.D.Biology research experienceMicrobiology techniquesBioprocess engineeringQuantitative research methodsQualitative research methodsSASROral communicationWritten communicationTeamworkTime managementOrganizational skills