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Pfizer · 20 hours ago

Principal Scientist, Primary Pharmacology

United States - Connecticut - Groton

Full-time

Onsite

Senior Level, Lead/Staff

$106K/yr - $172K/yr

4+ years exp

Pfizer is a leading biopharmaceutical company dedicated to delivering breakthroughs that transform patients' lives. The Principal Scientist in Primary Pharmacology will support and accelerate hit identification and lead optimization for small molecule drug discovery, utilizing expertise in pharmacology and target biology while collaborating with cross-disciplinary teams.

BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

No H1B

Responsibilities

Shape and support novel hit identification and optimization for small molecule drug discovery projects through application of in vitro pharmacology strategies for target-based and phenotypic projects

Independently design, develop, and perform in vitro assays to drive lead identification, SAR, and mechanistic pharmacology using a combination of biochemical and cellular systems

Design creative experiments and leverage diverse approaches to investigate target engagement, structure-function relationships, and molecular mechanism of action

Maintain a strong knowledge base in state-of-the-art technical developments and scientific advancements in the field and apply these innovatively to advance internal capabilities

Analyze and interpret data and as representative on project teams, communicate back clearly to collaborators and project teams

Be excited by working with cross-disciplinary groups (Disease Biology, Chemistry, Computational Biology, Structural Biology), be adept at building partnerships, and be team-oriented

Qualification

PharmacologyVitro assay developmentBiochemicalCellular systemsMolecular biology techniquesLaboratory automationData analysis systemsCollaboration skillsCommunication skillsMentoring

Required

BA/BS and 12 years or MS and 9 years or PhD and 4 years of relevant experience in biochemistry, cell biology and/or pharmacology

Demonstrated expertise with multiple in vitro assay formats (e.g. HTRF, ELISA, FP, BRET, etc) including assay troubleshooting and development. An ability to quickly learn new skills and knowledge on the job is critical

Practical experience with immortalized and primary cells and with molecular biology techniques such as RT-qPCR, transfection, and western blotting

Experience in laboratory automation and data analysis systems

Highly motivated, highly organized and possess excellent computer, verbal and written communication skills

Demonstrated ability to forge strong collaborative relationships inside and outside immediate team as well as cross disciplines

Experience mentoring junior colleagues