Associate Scientist/Senior Associate Scientist, Protein Sciences jobs in United States
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Manifold Bio · 17 hours ago

Associate Scientist/Senior Associate Scientist, Protein Sciences

positionBoston, MA
timeFull-time
remoteOnsite
seniorityMid, Senior Level
date5+ years exp

Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. The role involves expressing, purifying, and characterizing novel multispecific antibody drug formats while collaborating with a team of scientists and CROs.

BiotechnologyHealth CarePharmaceuticalTherapeutics
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H1B Sponsor Likelynote

Responsibilities

Maintain mammalian cell cultures and perform transient transfections to produce protein therapeutic candidates
Purify antibodies and other proteins using AKTA FPLC systems
Optimize purification processes using affinity, ion exchange, hydrophobic interaction, and size exclusion chromatography
Develop processes for optimized protein expression and purification
Characterize proteins using techniques such as SDS-PAGE, HPLC-SEC, DLS, and UV-Vis spectrophotometry
Test binding interactions using biolayer interferometry
Work with and manage CROs conducting protein production
Plan and perform experiments, analyze data, and present results in group meetings
Document experiments in an electronic lab notebook

Qualification

Mammalian protein expressionAKTA FPLC systemsAntibody purification techniquesProtein characterization methodsCRO managementCommunication skillsDetail-orientedTeam player

Required

BSc or MSc and 5+ years of industry experience
Expertise in mammalian protein expression and purification
Strong proficiency with AKTA FPLC systems
Knowledge of antibody purification techniques
Hands-on experience with secondary purification techniques such as IEX, HIC and MMC
Proficient with basic protein characterization methods such as SDS-PAGE, HPLC, UV-Vis
Hard-working, scientifically curious, and enthusiastic to contribute to cutting-edge work
Strong verbal and written communication skills
Detail-oriented and able to multitask
Able to work well as part of a team

Preferred

Experience managing CROs
Experience with expression optimization
Experience with purification optimization
Knowledge of DoE
Experience with high throughput protein production
Competency in protein characterization techniques such as SPR, BLI, DSF, DSC, cIEF, and CE-SDS

Company

Manifold Bio

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Manifold Bio is building a protein barcoding platform to bring the power of multiplexed measurement.
dateFounded in 2020
location
Boston, Massachusetts, USA
people-size11-50 employees
web-link
https://manifold.bio/

H1B Sponsorship

Manifold Bio has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2023 (1)
2021 (1)

Funding

Current Stage
Early Stage
Total Funding
$46.4M
Key Investors
Amazon Web ServicesTriatomic CapitalPlayground Global
2025-10-08Non Equity Assistance· $1M
2022-06-13Series A· $40M
2020-09-11Seed· $5.4M

Leadership Team

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Gleb Kuznetsov
Co-Founder and CEO
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Pierce Ogden
Co-Founder & CTO
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Recent News

BioSpace
Roche Makes Good on Dealmaking Promise With $1.1B Caris Cancer Collab
2025-12-17
Business Wire
Manifold Bio Expands Leadership Team to Drive its AI + In Vivo Targeted Biologics Platform
2025-12-15
Business Wire
Prothena Announces Board of Directors Update
2025-12-13
Company data provided by crunchbase