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AstraZeneca · 7 hours ago

Principal Engineer (Spray Drying)

Durham, NC

Full-time

Hybrid

Senior Level, Lead/Staff

$176K/yr - $264K/yr

5+ years exp

AstraZeneca is a leading pharmaceutical company seeking a Principal Engineer in Spray Drying within their Pharmaceutical Technology and Development department. This role is responsible for providing strategic leadership in spray drying processes, ensuring robust process development and compliance while driving innovation and technical excellence in drug product development.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Lead our engineering capability in spray drying, to design and develop robust manufacturing processes for new pharmaceutical formulations, ensuring scalability and compliance with industry standards

Evaluate, select, and specify spray drying equipment and technologies that best meet project and production requirements

Work effectively with colleagues across Global Product Development, and at our manufacturing partners, to define critical process parameters (CPPs) that influence product quality, in consideration of the wider product control strategy

Take the lead in defining the regulatory strategy for spray drying in drug products

Drive effective technical risk management to ensure that appropriate activities are conducted throughout development to deliver robust commercial manufacture

Expedite adoption and advancement of in silico process modelling and control in spray drying

Lead technology transfer, scale up and process validation approaches in spray drying

Provide leadership and coaching to other scientists and engineers within the group, supporting their development to build capability essential to the delivery of the present and future project portfolio

Demonstrate creativity and innovation, driving and supporting a culture of scientific excellence in projects

Stay updated on industry trends, emerging technologies, and best practices in spray drying to foster innovation within the organization

Qualification

Spray DryingPharmaceutical DevelopmentProcess ValidationPredictive Science ToolsStakeholder ManagementCollaboration SkillsOrganizational SkillsCommunication Skills

Required

BSc/PhD level education in a relevant Engineering field (Packaging Engineering, Mechanical Engineering, Biomedical Engineering, Materials Engineering, Chemical Engineering), or in Pharmaceutical Sciences with related experience in the device and biopharmaceutical industry is essential

Solid Dose Spray Drying experience

Minimum 5 years experience

Industrial experience in pharmaceutical spray drying with a degree in chemical engineering or a closely related scientific discipline

Experience and thorough understanding of the overall pharmaceutical drug product development and commercialization process, particularly in oral solid dose

Proven track record of delivering multiple and/or complex late stage spray drying drug product development projects, including technology transfer, scale up and validation

Experience of using predictive science / digital tools

Experience in development of drug product control strategies, bringing together different aspects of pharmaceutical sciences

Strong collaborative working and communication skills, including ability to work effectively with colleagues from diverse backgrounds and different skill areas

Good organizational and planning skills with the ability to deliver to agreed time and quality

Excellent stakeholder management skills

Preferred

Experience in development, scale up and technology transfer of a range of other drug product manufacturing processes, eg tablet compression, coating

Experience in clinical and commercial regulatory authoring and defense

Experience of working with external suppliers (such as CMO/CRO for outsourced development and supply) and managing productive relationships

Experience with inputting user requirements into capital projects

Benefits

Short-term incentive bonus opportunity

Equity-based long-term incentive program (salaried roles)

Retirement contribution (hourly roles)

Commission payment eligibility (sales roles)

Qualified retirement program [401(k) plan]

Paid vacation and holidays

Paid leaves

Health benefits including medical, prescription drug, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2021 (2)

2020 (11)