Bristol Myers Squibb · 23 hours ago
Senior Manager, Principal Software Engineer, Clinical Pharmacology and Pharmacometrics
Boston, MA
Full-time
Onsite
Senior Level, Lead/Staff
$165K/yr - $200K/yr
7+ years expBristol Myers Squibb is a company that focuses on transforming patients' lives through science. They are seeking a Senior Manager, Principal Software Engineer to lead the design, development, and deployment of innovative software and data platforms that support Clinical Pharmacology & Pharmacometrics, partnering closely with computational scientists and IT teams.
BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine
Responsibilities
Support deployment and operation of AI/ML models, simulation tools, and dashboards for scientific users
Lead the integration of HPC, cloud, and Kubernetes-based compute environments; optimize parallelization and resource utilization
Collaborate with domain scientists, IT, and other stakeholders to gather requirements and translate scientific workflows into robust technical solutions
Drive continuous improvement through automation, system upgrades, and stakeholder feedback
Manage platform security, validation, and compliance in coordination with IT and cybersecurity teams
Architect, develop, and maintain scalable software systems and data platforms for clinical pharmacology and pharmacometrics use cases
Mentor engineers and contribute to best practices (CI/CD, Agile)
Troubleshoot, monitor, and optimize performance of deployed systems
Qualification
Required
BS/MS/PhD in Computer Science, Software Engineering, or related field; higher degrees preferred
7+ years hands-on experience in software engineering, ideally in life sciences or healthcare domains
Proven track record architecting and delivering production-grade software and data platforms (preferably supporting scientific research, modeling or analytics)
Experience in cross-functional collaboration in matrixed, stakeholder-driven environments
Developer with programming skills in Python (primary) and R, integrating with API endpoints in AWS or Google cloud, knowledge of markdown languages such as Quarto/Typst
Demonstrated success building GenAI applications and agentic workflows, including fine-tuning and deploying LLMs. Proven experience working with LLM-based content ingestion, prompt engineering, and automating content generation involving complex tables, images, special characters, headers, footers, and merged columns to produce new reports from diverse source documents
Experience working of cloud services (AWS, Azure, GCP), HPC, Kubernetes, and parallel/distributed computing
Familiarity with software validation, compliance, and best practices in regulated environments
Understand all aspects of software development lifecycle
Understand various SDLC methodologies (Agile, Scrum, Waterfall etc.)
Familiarity with MATLAB, WebAPP
Excellent problem-solving, communication, and stakeholder engagement skills
Preferred
knowledge of vector databases and graph RAG would be a plus
Experience with Posit Workbench/RStudio Server, NAS integration, or similar collaborative scientific platforms
Knowledge of QSP, PBPK, PK/PD modeling or pharmaceutical R&D workflows
Experience implementing robust access controls, NFS, ACLs, and enterprise authentication
Agile and DevOps methodologies, CI/CD, and automation scripting (e.g., Bash, Ansible, CFT, Terraform)
Benefits
Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
Company
Bristol Myers Squibb
At Bristol Myers Squibb, we work every day to transform patients’ lives through science.
10001+ employees
H1B Sponsorship
Bristol Myers Squibb has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (247)
2024 (278)
2023 (231)
2022 (180)
2021 (181)
2020 (169)
Funding
Current Stage
Public CompanyTotal Funding
$29.32BKey Investors
Venrock
2025-11-05Post Ipo Debt· $5.74B
2024-02-14Post Ipo Debt· $13B
2023-10-30Post Ipo Debt· $4.5B
Leadership Team
Charles Bancroft
CFO
Cristian Massacesi
Executive Vice President, Chief Medical Officer and Head of Development
Recent News
2026-01-08
2026-01-07
2026-01-07
Company data provided by crunchbase