Bristol Myers Squibb · 22 hours ago
Senior Scientist, Discovery BioSciences Oncology
Cambridge Crossing - MA - US
Full-time
Onsite
Mid, Senior Level
$138K/yr - $167K/yr
2+ years expBristol Myers Squibb is a leading biopharmaceutical company focused on discovering and developing innovative medicines. The Senior Scientist will be responsible for advancing oncology drug discovery programs, focusing on cancer immunology and biotherapeutic target identification, validation, and optimization studies.
BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine
Responsibilities
Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning, western blotting, immunoprecipitation, ELISA, and MSD
Experience with in vivo oncology and/or immunology models. Animal handling is not a requirement, but the candidate should understand the strengths and weaknesses of commonly used cancer immunology models, and have experience with downstream tissue processing (dissociation, flow cytometry, IHC)
Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
Design, optimize, and troubleshoot complex cell-based and in vivo assays to evaluate therapeutic candidates and understand cancer signaling pathways
Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
Contribute to the preparation of technical reports, publications, and presentations
Qualification
Required
Bachelor's Degree + 7+ years of academic and / or industry experience
Master's Degree + 5+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in the Life Sciences + 2+ years of academic and / or industry experience
Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning, western blotting, immunoprecipitation, ELISA, and MSD
Experience with in vivo oncology and/or immunology models. Animal handling is not a requirement, but the candidate should understand the strengths and weaknesses of commonly used cancer immunology models, and have experience with downstream tissue processing (dissociation, flow cytometry, IHC)
Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
Design, optimize, and troubleshoot complex cell-based and in vivo assays to evaluate therapeutic candidates and understand cancer signaling pathways
Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
Contribute to the preparation of technical reports, publications, and presentations
Preferred
PhD and 2+ years of academic and / or industry experience preferred
Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (e.g. ADCs, multi-specifics, and TCEs) is strongly preferred
Proven track record with designing and developing a variety of molecular biology and cellular assays
Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
Proficiency in data analysis software (e.g., GraphPad Prism, FlowJo) and familiarity with bioinformatics tools
Familiarity with querying large-scale oncology datasets (DepMap, cBioPortal, TCGA) to generate and test hypotheses
Effective troubleshooting skills when optimizing assays and when developing innovative methodologies
Benefits
Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
Company
Bristol Myers Squibb
At Bristol Myers Squibb, we work every day to transform patients’ lives through science.
10001+ employees
H1B Sponsorship
Bristol Myers Squibb has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (247)
2024 (278)
2023 (231)
2022 (180)
2021 (181)
2020 (169)
Funding
Current Stage
Public CompanyTotal Funding
$29.32BKey Investors
Venrock
2025-11-05Post Ipo Debt· $5.74B
2024-02-14Post Ipo Debt· $13B
2023-10-30Post Ipo Debt· $4.5B
Leadership Team
Charles Bancroft
CFO
Cristian Massacesi
Executive Vice President, Chief Medical Officer and Head of Development
Recent News
2026-01-08
2026-01-07
2026-01-07
Company data provided by crunchbase