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Bayside Solutions · 22 hours ago

Principal Scientist or Director

Irvine, CA

Full-time

Onsite

Senior Level, Lead/Staff, Director/Executive

$120K/yr - $140K/yr

7+ years exp

Bayside Solutions is a fast-growing, AI-driven biotherapeutics company dedicated to rapidly generating next-generation biologics for Immunology & Inflammation and metabolic diseases. They are seeking a highly motivated Principal Scientist or Director to lead the design and optimization of monoclonal antibodies and collaborate with cross-functional teams to evaluate therapeutic candidates.

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Growth Opportunities

Responsibilities

Lead the design, discovery, and optimization of monoclonal, bispecific, and multispecific antibodies using display and screening platforms (B-cell cloning, phage, and yeast display)

Perform high-throughput antibody screening assays, including binding kinetics, ligand blocking, and epitope binning, to rapidly identify and prioritize lead candidates

Design and develop recombinant protein-based immunoassays to characterize therapeutic antibodies using biochemical and biophysical methods

Execute small- and large-scale antibody expression and purification using chromatography techniques and evaluate purity via SDS-PAGE, analytical SEC, and Western blot

Co-lead biotherapeutic discovery campaigns and partner closely with in vitro and in vivo pharmacology teams to evaluate PK/PD, efficacy, and safety profiles

Provide strategic and technical input on antibody design, developability, and candidate selection during early-stage development

Interface with CROs and external collaborators to ensure high-quality data generation and timely project execution

Present experimental results and program updates to project teams, senior management, and collaborators

Maintain accurate experimental documentation in ELN and ensure compliance with best data practices

Stay current with emerging literature and technologies relevant to antibody engineering and biologics discovery

Qualification

Antibody discoveryProtein engineeringBiotherapeutic discoveryData analysis softwareHigh-throughput screeningImmunoassay developmentChromatography techniquesExperimental designCommunicationProblem-solving skillsTeam collaborationAttention to detail

Required

PhD in Biochemistry, Biomedical Engineering, Molecular Biology, Immunology, or related discipline with at least 7 years (Principal Scientist) or 10 years (Director) of research experience working in a biotech or large pharma setting is a must

Experience with antibody pipeline discovery, screening, antibody engineering, and optimization in the field of I&I or metabolic diseases is a must

Expertise in designing and conducting in vitro protein-based assays using diverse biophysical and bioanalytical methods (e.g., SPR/BLI, ELISA, DLS, thermal stability, immunoassays) is a must

A strong understanding of protein engineering, Fc modifications, and developability assessments is essential

Ability to work independently and as part of a team in a fast-paced environment, with strong analytical and problem-solving skills, and attention to detail is essential

Strong communication and interpersonal skills, with the ability to present complex data clearly to cross-functional teams, leadership, and collaborators

Self-motivated, collaborative, and enthusiastic about contributing to a multidisciplinary, early-stage biotech focused on breakthrough antibody therapeutics