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Arrowhead Pharmaceuticals · 1 day ago

Summer Intern, Mechanistic Pharmacology - RNAi Mechanisms & Functional Genomics

Madison, Wisconsin, United States

Internship

Onsite

Intern

$21/hr - $21/hr

Arrowhead Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company focused on developing innovative drugs that treat intractable diseases through RNA interference. The Mechanistic Pharmacology Intern will support discovery research by contributing to studies that enhance understanding of RNAi mechanisms and pharmacodynamics, working closely with experienced scientists on defined research projects.

BiotechnologyHealth CareNanotechnologyPharmaceutical

Comp. & Benefits

No H1B

Responsibilities

Complete onboarding activities including shadowing team members, skill assessments, learning core laboratory techniques, and reviewing foundational scientific background

Execute one of two predefined research projects within the Mechanistic Pharmacology group

Support execution of a CRISPR-based screening project to identify cellular pathways and factors that enable productive RNAi-mediated target gene knockdown, including analysis and validation of screening hits

Support studies investigating the relationship between cellular uptake, RISC loading, and mRNA degradation activity to better understand RNAi pharmacokinetics and pharmacodynamics

Learn and apply laboratory methodologies fundamental to Mechanistic Pharmacology research, including:

Tissue culture

Quantitative PCR (qPCR)

SiRNA and plasmid transfection

Protein biochemistry and analysis

Confocal and live-cell fluorescence microscopy

Flow cytometry

Collect, analyze, and interpret experimental data using tools such as GraphPad Prism, FACSDiva, FlowJo, Design and Analysis (Thermo Fisher), CellProfiler, ZEN Suite, ImageJ/FIJI, Microsoft Excel, and Benchling

Read and critically evaluate primary scientific literature to contribute to hypothesis generation and data interpretation

Present project updates in weekly group meetings

Prepare final deliverables, including a scientific poster and a ~20-minute presentation summarizing project objectives, results, and learnings

Qualification

RNAi mechanismsQuantitative PCR (qPCR)CRISPR-based screeningCell biologyProtein biochemistryFlow cytometryMicrosoft OfficeLaboratory techniquesCommunication skillsProblem-solving skillsOrganizational skills

Required

Currently enrolled in a bachelor's degree program at an accredited university or college and majoring in a scientific discipline such as Biochemistry, Biology, Chemistry, Engineering, Genetics, or a related scientific discipline

Excellent verbal and written communication skills, including comfort presenting in group settings

Strong problem-solving and organizational skills

Proficiency in Microsoft Office applications

Ability to lift up to 40 lbs

Willingness and ability to spend 75% of the workday walking the facility and 25% at a desk