Broad Institute of MIT and Harvard · 22 hours ago
Research Scientist I - MDL
Cambridge, MA
Full-time
Onsite
Entry, Mid Level
$88K/yr - $124K/yr
2+ years expThe Broad Institute of MIT & Harvard is seeking a highly motivated and experienced Research Scientist I to join the Methods Development Lab (MDL). This role focuses on the development and application of methods for ultra high-throughput single-cell multiomic sequencing technologies, requiring collaboration with both experimental and computational scientists to drive scientific innovation.
BiotechnologyClinical TrialsLife Science
Responsibilities
Design, implement, and rigorously optimize next-generation single-cell multiomic methods
Establish and maintain Standard Operating Procedures (SOPs) for novel and established high-throughput sequencing assays to ensure reproducibility and scalability
Troubleshoot complex molecular biology and sequencing workflows at every step, from sample preparation to library construction
Execute complex and detailed experimentation on a daily basis, utilizing advanced molecular biology techniques
Culture primary and established cell lines under BSL-2 conditions for methods validation and application studies
Work closely with computational biologists to co-develop analytic methods for novel technologies, and interpret large-scale single-cell datasets to strategically inform experimental design iterations
Collaborate seamlessly with the development team and external Broad Labs to successfully transition developed methods for use in large-scale biological applications
Critically evaluate and present results, methodology, and insights clearly at weekly group and inter-departmental meetings
Contribute substantively to the writing and preparation of high-impact manuscripts, grant proposals, and community resources
Maintain deep and current knowledge of the single-cell and functional genomics fields, proactively identifying and evaluating new -omic technologies and tools for potential utility and fit within the Broad's capabilities
Actively participate in the preparation of funding applications (federal, philanthropic, institutional, or industrial)
Seek intellectual property protection for inventions that are conceived of or developed while a member of the MDL
Qualification
Required
Ph.D. degree in Molecular Biology, Genetics, Bioengineering, or a related field with 2+ years of relevant, post-graduate work experience in an academic or industrial lab setting, OR a Master's degree with 5+ years of relevant experience
Extensive, hands-on molecular biology expertise is mandatory, including proficiency in the execution of single-cell sequencing pipelines from sample collection/preparation through library construction and sequencing coordination
Direct experience with commercial and/or custom single-cell platforms is required
Proven expertise in single-cell RNA-seq and related sequencing modalities, with a strong, demonstrable emphasis on methods development, optimization, and multiomic approaches (CITE-seq, Perturb-seq)
Expertise in BSL2 cell culture, including the handling and processing of primary human/mouse cells and induced Pluripotent Stem Cells (iPSCs)
Must be forward-thinking and highly innovative, with a nimble scientific/technical mind, able to rapidly develop and execute on creative solutions to technical roadblocks
Strong ability to work both independently and collaboratively. Proven experience working effectively across experimental and computational research groups in a fast-paced, matrixed environment
Excellent written and verbal communication skills, especially the ability to clearly and concisely describe complex experimental methods and interpret results to diverse audiences (both scientific and non-scientific)
Ability to thrive in a fast-paced, rapidly changing environment
Preferred
Experience with 10X Genomics, PIPseq is strongly preferred
Direct experience in the design, execution, and data interpretation of single-cell functional genomic perturbation screens (e.g., Perturb-seq, CRISPR-based screens) is highly preferred
Background in analyzing and interpreting complex sequencing data, including familiarity with relevant programming/scripting languages (R or Python) is preferred
A publication history in peer-reviewed journals, especially those focused on novel sequencing methodologies, is strongly preferred
Benefits
Medical
Dental
Vision
Life
Disability insurance
A 401(k) retirement plan
Flexible spending and health savings accounts
At least 13 paid holidays
Winter closure
Paid time off
Parental and family care leave
An employee assistance program
Among other Broad benefits
Company
Broad Institute of MIT and Harvard
The Broad Institute brings together a diverse group of individuals from across its partner institutions — undergraduate and graduate students, postdoctoral fellows, professional scientists, administrative professionals, and academic faculty.
1001-5000 employees
H1B Sponsorship
Broad Institute of MIT and Harvard has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (108)
2024 (59)
2023 (73)
2022 (68)
2021 (70)
2020 (93)
Funding
Current Stage
Late StageTotal Funding
$283.25MKey Investors
MacArthur FoundationAlzheimer's Foundation of AmericaMassachusetts Life Sciences Center
2025-11-18Grant· $100M
2020-08-11Grant
2019-09-09Grant· $0.75M
Leadership Team
Dan Shore
Chief Financial Officer
Anne Carpenter
Institute Scientist and Imaging Platform Senior Director
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