Twist Bioscience · 2 days ago
Scientist/ Sr Scientist / Staff Scientist (DNA Synthesis Process Development)
South San Francisco, CA
Full-time
Onsite
New Grad, Entry, Mid, Senior Level, Lead/Staff
$127K/yr - $190K/yr
0+ years expTwist Bioscience is a company focused on DNA synthesis, aiming to innovate in the field of genomics. They are seeking a 'Triple Threat' Scientist with a strong background in Molecular Biology, DNA Chemistry, and data analysis skills to contribute to their R&D efforts in DNA synthesis process development.
B2BBiotechnologyChemicalHealth CareLife Science
Responsibilities
Design and execute downstream validation workflows for new synthesis chemistries
Perform complex nucleic acid enzymology: Utilizes the full range of enzymatic tools (polymerases, ligases, nucleases, kinases) to repair, modify, and assemble DNA from chip to library
Execute NGS Library Prep: Select and run the appropriate library prep workflows (Illumina/Nanopore) to reveal specific synthesis error modes
Code your own analysis: Use Python or R to analyze NGS data, generate figures, and correlate biological performance with upstream synthesis conditions
Troubleshoot synthesis issues by understanding the phosphoramidite cycle and identifying chemical shortcomings
Move projects forward efficiently and prioritize tasks in accordance with the company’s goals
Qualification
Required
Experience in Molecular Biology, Genomics, Biochemistry, or combination of closely-related field and experience
Scientist Requires a PhD and 0-2 years of previous professional experience; or a master's degree and 3-5 years of work experience
Sr Scientist Requires a Ph.D. and 2-5 years of professional experience (postdoc may count); or a master's degree and 5-7 years of work experience
Staff Scientist Requires a Ph.D. and 5-8 years of professional experience (postdoc may count); or a master's degree and 7 years of work experience
Expert Enzymology: You know anything an enzyme can do on a nucleic acid. Deep hands-on experience with complex manipulations, gene construction, and repair workflows
Handling Modified Templates: Experience amplifying or manipulating nucleic acids with non-standard modifications (e.g., stability mods, backbone changes, or novel linkers)
DNA Chemistry Literacy: Must understand the fundamentals of the DNA synthesis cycle (coupling, deblocking, oxidation) and how errors arise
Coded Data Analysis: Proven ability to use Python or R to analyze experimental results (sequencing alignment, error rate calculation, plotting)
Comfortable working in a fast-paced R&D environment
Benefits
Bonus
Equity
Generous benefits package
Company
Twist Bioscience
Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.
501-1000 employees
H1B Sponsorship
Twist Bioscience has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (14)
2023 (22)
2022 (19)
2021 (4)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$553.11MKey Investors
Capital World InvestorsBiomatics Capital PartnersIllumina
2022-02-09Post Ipo Equity· $250M
2020-01-27Post Ipo Equity· $50M
2018-10-30IPO
Leadership Team
Emily Leproust
CEO
Siyuan Chen
Chief Technology Officer
Recent News
2026-01-07
2025-12-30
Company data provided by crunchbase