Oxford BioTherapeutics · 12 hours ago
Antibody Discovery Associate Scientist/Scientist
San Jose, CA
Full-time
Onsite
Mid, Senior Level
1+ years expOxford Biotherapeutics (OBT) is a clinical-stage biotechnology company focused on developing innovative antibody-based therapeutics for cancer treatment. The Antibody Discovery Associate Scientist/Scientist will play a crucial role in discovering therapeutic antibodies using advanced in vivo and in vitro techniques while collaborating with cross-functional teams in a fast-paced environment.
BiotechnologyGeneticsHealth CareHealth DiagnosticsTherapeutics
Hiring Manager
Almudena Heredia Usero
Responsibilities
Single B‑cell discovery: Plan and execute multiparameter flow cytometry for antigen‑specific B‑cell sorting; recover paired VH/VL sequences using single‑cell RT‑PCR; perform molecular cloning and antibody expression for rapid screening
Molecular recovery & sequencing: Develop and perform workflows for RT‑PCR/PCR, barcoding, and amplicon QC; prepare NGS libraries and support sequencing for deep repertoire capture
Repertoire mining & clonal analysis: Analyse BCR repertoires (VDJ assignment, CDR annotation), perform clonal clustering and lineage inference, and identify promising antibodies using developability/sequence‑liability assessments
High‑throughput screening (HTS): Run ELISA, Octet, and cell‑based assays to assess specificity, affinity, and expression levels
Antibody characterisation: Perform kinetics and epitope binning (BLI/SPR), assess cross‑reactivity and affinity maturation, and contribute to mechanism‑of‑action assays
Data analysis & reporting: Own QC, analysis, and visualisation of experimental data; prepare clear written summaries and present findings to internal and external partners
Operational excellence: Maintain high‑quality scientific records, support workflow optimisation, and uphold lab safety and data integrity
Qualification
Required
BS/MS/PhD in Immunology, Molecular Biology, Biochemistry, Cell Biology, or a related field
BS/MS: 3–5 years' hands‑on experience in antibody discovery (industry preferred)
PhD: 1–2 years' experience
Experience with flow cytometry/FACS for antigen‑specific B‑cell sorting (SONY sorter experience a plus)
Proficiency in single‑cell RT‑PCR, PCR, cloning, expression, and sequence analysis
Experience with NGS workflows — library prep, indexing, QC — and repertoire analysis tools (e.g., MiXCR, IgBLAST, PipeBio)
Familiarity with SPR/BLI for kinetics and epitope binning
Competence in data analysis software such as FlowJo, Geneious Prime, Biacore/Octet, and GraphPad Prism
Strong written and verbal communication skills
Preferred
Experience with CRISPR gene editing
Understanding of antibody developability assessment
Benefits
Medical, dental, and vision insurance for employees and dependents
Flexible Spending Account (FSA)
Short‑Term Disability (STD), Long‑Term Disability (LTD), Basic Life & AD&D, and Supplemental Life insurance
401(k) plan
120 hours of Paid Time Off + 5 sick days per year
11 public holidays
Annual bonus program
Employee referral bonus program
New hire stock options
Company
Oxford BioTherapeutics
Oxford BioTherapeutics develops medicines for cancer and companion diagnostics for selected antibody programs.
11-50 employees
H1B Sponsorship
Oxford BioTherapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2020 (1)
Funding
Current Stage
Early StageTotal Funding
$33.22MKey Investors
Calculus CapitalOxford Finance LLCSilicon Valley Bank
2021-01-01Series Unknown
2018-08-03Series Unknown· $2.6M
2017-01-26Debt Financing· $10M
Leadership Team
Abderrahim Fandi, MD PhD
Chief Medical Officer
Joyce B.
Human Resources and Office Business Partner
Recent News
2025-12-15
MarketScreener
2025-12-10
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