Sartorius · 12 hours ago
Principal Scientist - Upstream Process Development - Onsite - Marlborough, MA
Marlborough, MA
Full-time
Onsite
Senior Level, Lead/Staff
6+ years expSartorius is a global life science company engaged in innovative biomanufacturing solutions. The Principal Scientist will lead process development for viral vectors and monoclonal antibodies, optimizing protocols and managing cross-functional teams to ensure scalable manufacturing processes.
BiotechnologyHealth CareManufacturingPharmaceutical
Responsibilities
Design and optimize protocols for the culture and growth of primary cells and cell lines (e.g. HEK, CHO and Vero) using cutting-edge techniques aimed at enhancing the efficiency and scalability of the processes
Lead cross-functional teams, to scale primary cell and cell line expansion and from benchtop to production scale bioreactors
Develop and write process development proposals, conduct hands-on laboratory work to optimize and troubleshoot upstream manufacturing processes for Viral Vectors, mAbs and other biologics
Analyze and interpret data ensuring clear documentation of methodologies and outcomes
Prepare detailed reports and presentations for internal and external partners to communicate progress in line with project schedules
Assist in mentoring and training junior team members and coordinating the day-to-day operations
Lead and manage multiple high impact internal and external research projects by establishing priorities, milestones, schedules, and deadlines. Responsible for writing, reviewing, and maintaining electronic lab notebooks with the highest level of research integrity
Responsible for writing project reports, briefs, protocols and making presentations to internal and external partners and project teams as required. Lead technology transfer activities to internal and external collaborators
Support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences
Conduct technical investigations and risk assessments related to processes
Support generation of protocols, work instructions, batch records and reports
Work independently in a matrixed environment
Perform occasional extended hours and weekends to support ongoing lab activities as needed
Mentor and support junior staff and build a culture of support and collaboration
Comply with all site policies such as record retention, ISO requirements, and accountable for good housekeeping in all laboratories
Comply with biohazard, special clean room and site safety/health procedures and guidelines as required
Assist other team members and site management team with miscellaneous duties when requested
Qualification
Required
Master's with 10+ years of industry experience or a Ph.D. with 6+ years of industry experience in chemical, biochemical or biomedical engineering, engineered cell therapies or related field
Extensive expertise in culturing cell types relevant to advanced therapy applications
Expertise in adapting existing cell culture processes from planar to 3D bioreactor systems
Hands-on experience with microcarrier-based suspension culture and single cell cloning is a plus
Knowledge of GxPs, experience in process development or GMP operation is a plus
Demonstrated ability to design, plan, and implement pluripotent cell differentiation protocols
Experience in the design and execution of current molecular biology and biochemical assay techniques including PCR, qPCR, ddPCR, NGS, WB, IF, ELISA, and Flow Cytometry is highly desirable
Experience & knowledge of state-of the-art upstream and downstream technologies for cell growth, transfection, propagation, and purification for application for process development workflow
Experience working as part of multi-partner R&D projects
Strong analytical and mathematical ability
Ability to work independently and constructively in a team environment
Must have strong personal initiative and be results oriented
Strong troubleshooting skills
Experience with documentation control systems
Familiarity with relevant guidelines from the FDA, EMA and ICH
Strong written and verbal communication skills, capable of clearly expressing technical concepts to people with various levels of technical expertise and diverse cultural backgrounds
Identification with our core values: Sustainability, Openness, Enjoyment
Benefits
Personal and Professional Development: Mentoring, leadership programs, internal seminar offerings
Worklife Balance: Paid vacation, sick time, corporate holidays and community service day; as well as flexible work schedules
Making an Impact Right from the Start: Comprehensive onboarding, including a virtual online platform
Welcoming Culture: Mutual support, team spirit and international collaboration; communities on numerous topics such as “Coaching”, “Agile Working” and a “Businesswomen’s Network”
Health & Well Being: Wide selection of health and well-being support such as a variety of medical plans to choose from, dental, vision, EAP, and other wellness programs.
Intelligent Working Environment: Working in smart buildings with the latest technology and equipment.
Retirement Savings Plan: 401 k (with generous company match)
Flexible Spending: HSA, FSA (dependent care & healthcare spending), Transportation Commuter Account
Company Paid Benefits: Basic Life Insurance, AD&D, EAP, Family Planning & Women’s Health, Health Advocate
Additional/Optional: Supplemental Life Insurance (employee, spouse & dependents), Legal Services, LTD & STD, Critical Illness Insurance, Student Loan Tuition Refinance Service
Company
Sartorius
Sartorius helps its customers to develop and manufacture biotech medicines reliably, quickly, and economically. It is a sub-organization of Sartorius.
10001+ employees
H1B Sponsorship
Sartorius has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (16)
2024 (27)
2023 (14)
2022 (21)
2021 (24)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$3.21B2023-09-07Post Ipo Debt· $3.21B
1990-07-10IPO
Leadership Team
Joachim Kreuzburg
Chairman of the Executive Board | CEO
Florian Funck
Member of the Executive Board | CFO
Recent News
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