Children's Hospital of Philadelphia Research Institute ยท 1 day ago
Postdoctoral Research Scientist
Philadelphia, PA
Full-time
Onsite
New GradChildren's Hospital of Philadelphia Research Institute is seeking a Postdoctoral Research Scientist to develop strategies for enhancing antigen presentation in immunologically cold tumors. The role involves engineering HLA class I antigen processing components and conducting various immunological experiments to aid in cancer immunotherapy, particularly focusing on pediatric neuroblastoma.
Research
Responsibilities
Design and engineer HLA-I chaperones and APP pathway components
Conduct high-throughput immunopeptidomics experiments to identify novel antigens
Perform cellular immunology assays including HLA trafficking studies, single-molecule tracking, and T cell functional assays
Collaborate with clinical and translational teams to validate therapeutic targets
Mentor graduate students and contribute to grant writing and manuscript preparation
Qualification
Required
PhD in immunology, biochemistry, molecular biology, or related field
Strong background in experimental immunology
Experience with mammalian cell culture, flow cytometry and cell-based assays
Excellent written and oral communication skills
Ability to work independently and collaboratively in a multidisciplinary environment
Preferred
Experience with mass spectrometry-based proteomics or immunopeptidomics
Knowledge of HLA biology and antigen presentation pathways
Experience with flow cytometry, live-cell imaging, or super-resolution microscopy
Background in cancer immunology or immunotherapy development
Benefits
Highly collaborative environment with ongoing partnerships across multiple leading groups
Access to state-of-the-art proteomics, imaging, and immunology core facilities at CHOP/UPenn
Opportunities to contribute to translational projects with direct clinical impact
Support for career development and publication in high-impact journals
Competitive salary and benefits package
Company
Children's Hospital of Philadelphia Research Institute
We advance the health of children by turning scientific discovery into medical innovation.
Founded in 1922
5001-10000 employees
Funding
Current Stage
Late StageLeadership Team
Jean-Bernard Lubin
Postdoctoral Fellow in PennCHOP Microbiome program
Tom Privette, Ph.D.
Head, Office of Entrepreneurship & Innovation, Business Development & External Partnering
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