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Salubris Biotherapeutics · 1 week ago

Senior Director/Vice President, Preclinical Pharmacology & Toxicology

Gaithersburg, MD

Full-time

Onsite

Director/Executive

10+ years exp

Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as Senior Director or Vice President, Preclinical Pharmacology & Toxicology. This foundational leadership role offers the opportunity to further establish and lead the Preclinical Pharmacology, Pharmacometrics, and Toxicology function, driving research programs from lead optimization through IND submission.

BiotechnologyHealth CarePharmaceutical

Responsibilities

Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategy across the portfolio

Drive the strategic vision for advancing programs from late-stage discovery through IND/CTA submission, ensuring alignment with corporate objectives and competitive positioning

Anticipate regulatory and scientific challenges, and proactively develop risk mitigation strategies to accelerate program timelines

Design, manage, and interpret pharmacology, PK/PD, and toxicology studies (GLP/non-GLP) to support program advancement

Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages

Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies

Ensure seamless translation of preclinical findings into clinical development plans

Mentor and develop internal team members, building organizational capabilities in disease- and target-relevant efficacy studies, PK/PD/biomarker strategies, and translational approaches across cardiovascular/metabolic and oncology therapeutic areas

Qualification

PhD in relevant field10+ years industry experienceLeadership in preclinical pharmacologyVivo pharmacology knowledgeBioanalysisDMPK knowledgeBiologicsCardiovascular/metabolic experienceOncology experienceSelf-motivated leaderStrategic thinkingCommunication skillsInterpersonal skillsCollaborative work

Required

PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline

10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical pharmacology, toxicology, and/or DMPK

Demonstrated ability as program lead to advance programs from lead optimization to IND with complex biologics, such as antibodies, and/or antibody conjugates (ADCs, AOCs)

Deep understanding of in vivo pharmacology and toxicology

Solid working knowledge in bioanalysis, PK/PD, and DMPK. Relevant experience with both biologics and small molecules is a strong plus

Experience delivering high-quality preclinical/nonclinical data packages for drug candidate selection and IND-enabling studies

Preferred

Experience with cardiovascular/metabolic therapeutic area or oncology preferred

Benefits

Competitive compensation package including base salary

Performance bonus

Equity participation

Comprehensive benefits

Company

Salubris Biotherapeutics

SalubrisBio was founded in August 2016 as a subsidiary of the China-based pharmaceutical company Salubris Pharmaceuticals Co. Ltd. (www.salubris.com).

Founded in 2016

Gaithersburg, Maryland, USA

11-50 employees