Senior Machine Learning Engineer jobs in United States
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Paradigm Health · 17 hours ago

Senior Machine Learning Engineer

Paradigm Health is rebuilding the clinical research ecosystem by enabling equitable access to trials for all patients. As a Senior Machine Learning Engineer, you will lead the design and deployment of sophisticated ML models to optimize clinical trial workflows and patient engagement, impacting healthcare significantly.

Health CareHealth DiagnosticsHospitalLife Science
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H1B Sponsor Likelynote

Responsibilities

Lead the development, testing, and deployment of ML models and pipelines, with a focus on scalability and integration into production systems
Design and refine GenAI/LLM-based models to streamline and automate clinical trial operations, from data gathering to real-time performance monitoring
Partner with clinicians, informaticists, data scientists, and engineers to build solutions aligned with Paradigm’s mission and goals
Drive improvements in model deployment infrastructure, develop monitoring tools, and refine model performance to ensure robust production-level reliability
Mentor junior ML engineers, contributing to team knowledge-sharing and establishing best practices for data science and machine learning
Present complex technical insights and results to both technical and non-technical stakeholders, advocating for data science-driven strategies that align with business objectives

Qualification

Machine LearningGenAI/LLMPythonSQLCloud InfrastructureProduction-Level PipelinesStartup MindsetHealthcare ExperienceProblem SolvingCollaboration

Required

Master's or PhD in computer science, statistics, machine learning, or a related field
5+ years of experience as a machine learning engineer, with a proven track record in healthcare, life sciences, or a related field
Deep expertise in training, fine-tuning, and deploying ML models, including experience with GenAI/LLMs
Proficiency in Python, SQL, and familiarity with cloud infrastructure and ML engineering best practices
Experience managing production-level pipelines, including model deployment, monitoring, and continuous integration
Advanced analytical skills and a collaborative approach to solving complex challenges across teams
Adaptability and experience in fast-paced, mission-driven environments with high levels of ambiguity

Preferred

Background in working with oncology or clinical trial data
Hands-on experience developing and deploying GenAI/LLM-based models and open-source frameworks for LLM applications
Previous involvement in an early-stage startup, ideally in health tech or life sciences, with a passion for high-growth projects

Benefits

Competitive health, dental, and vision insurance
Mental health support for you and your family through Spring Health
Equity package
Unlimited paid time off (PTO)
16 weeks of paid parental leave
Flexible work options – remote and hybrid arrangements
Company-paid life insurance
Company-paid short-term and long-term disability coverage
One Medical membership
401(k) plan with company match

Company

Paradigm Health

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Paradigm Health is rebuilding the clinical research ecosystem by creating a platform that enables equitable access to trials for all patients, while enhancing trial efficiency and reducing the barriers to participation for healthcare providers.

H1B Sponsorship

Paradigm Health has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (4)
2023 (1)
2022 (1)
2021 (4)
2020 (1)

Funding

Current Stage
Growth Stage
Total Funding
$281M
Key Investors
ARCH Venture Partners
2025-12-04Series B· $78M
2023-01-25Series A· $203M

Leadership Team

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Paul Kluetz
Chief Medical Officer
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Company data provided by crunchbase