Natera · 1 day ago
Principal Software Architect
United States
Full-time
Remote
Lead/Staff
$183K/yr - $229K/yr
12+ years expNatera is a global leader in cell-free DNA testing, dedicated to oncology, women's health, and organ health. They are seeking a visionary Principal Software Architect to lead the design and evolution of intelligent, high-scale systems, focusing on architectural strategy and collaboration across teams.
BiotechnologyGeneticsHealth DiagnosticsMedicalWomen's
Responsibilities
Define and own architectural strategy across product lines, ensuring alignment with long-term technical and business goals
Design and evolve cloud-native systems with a focus on scalability, maintainability, observability, and security
Create architectural blueprints and reusable frameworks that guide teams in building high-performance services and user-facing applications
Act as a technical thought partner to engineering leadership, product managers, and executive stakeholders
Mentor senior engineers and architects, cultivating a culture of system thinking and technical excellence
Drive architectural governance, setting standards, conducting reviews, and managing risk across projects
Lead modernization initiatives, including migration from monolithic to service-oriented or event-driven architectures
Evaluate and introduce emerging technologies that improve developer productivity and system resilience
Partner with AI/ML teams to ensure scalable integration of intelligent services and real-time analytics
Work closely with teams to guide solution design, decomposition, and trade-off decisions
Support high-priority projects through planning, hands-on design sessions, and technical troubleshooting
Maintain a system-level view of infrastructure, services, and data flows to anticipate bottlenecks and scale risks
Qualification
Required
12+ years of professional software engineering experience, with 6+ years in a senior architectural leadership role
Deep experience designing and scaling enterprise software systems, particularly in cloud-native environments (AWS preferred)
Proven success with architectural transformation initiatives (e.g., service decomposition, domain-driven design, platform re-architecture)
Strong understanding of architectural trade-offs in system design (performance, resilience, cost, etc.)
Excellent communication skills with the ability to explain complex technical concepts to both technical and non-technical audiences
Preferred
Experience with scientific, healthcare, or lab operations domains
Familiarity with LIMS/LES systems, AI integration patterns, or regulated software environments
Benefits
Annual performance incentive bonus
Long-term equity awards
Comprehensive health benefits (medical, dental, vision)
401(k) with company match
Generous paid time off and company holidays
Additional wellness and work-life benefits
Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
Free testing in addition to fertility care benefits
Pregnancy and baby bonding leave
Commuter benefits
Generous employee referral program
Company
Natera
Natera specializes in cell-free DNA testing to provide a more targeted interventions to oncology, women's health, and organ health.
5001-10000 employees
H1B Sponsorship
Natera has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (90)
2024 (72)
2023 (37)
2022 (71)
2021 (64)
2020 (40)
Funding
Current Stage
Public CompanyTotal Funding
$1.16BKey Investors
Sofinnova InvestmentsLightspeed Venture PartnersSequoia Capital
2023-09-07Post Ipo Equity· $250M
2022-11-15Post Ipo Equity· $400.05M
2022-03-16Post Ipo Equity· $5M
Leadership Team
Steve Chapman
CEO
Jonathan Sheena
Co-Founder, Board Member
Recent News
2026-01-08
Company data provided by crunchbase