Amgen · 13 hours ago
Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead
US - California - Thousand Oaks
Full-time
Hybrid
Senior Level, Lead/Staff
$184K/yr - $205K/yr
3+ years expAmgen is a biotechnology company dedicated to serving patients living with serious illnesses. In this role, you will lead the strategy and execution of innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples, contributing to the advancement of siRNA therapeutics from discovery to clinical proof of concept.
BiotechnologyHealth CareManufacturingPharmaceutical
Responsibilities
Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo)
Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates
Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates
PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities
Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications
Mentor and cross-train PKDM-BA scientific colleagues
Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept
Qualification
Required
Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience
Master's degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience
Bachelor's degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience
Preferred
Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics; Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules is also highly desirable
Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
Expertise in antibody-siRNA bioanalytical approaches and considerations
Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms; Experience with respect to RT-qPCR and/or RT-ddPCR is also highly desirable
Exceptional written and verbal communication skills
Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics
Benefits
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible.
Company
Amgen
Amgen is a biotechnology company that develops and manufactures human therapeutics for various illnesses and diseases.
10001+ employees
H1B Sponsorship
Amgen has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (429)
2024 (485)
2023 (485)
2022 (540)
2021 (460)
2020 (444)
Funding
Current Stage
Public CompanyTotal Funding
$28.5B2022-12-12Post Ipo Debt· $28.5B
1983-06-17IPO
Leadership Team
Robert Bradway
Chairman and Chief Executive Officer
Jay Bradner
Executive Vice President of R&D, and Chief Scientific Officer
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