Revolution Medicines · 10 hours ago
Senior Scientist I, Toxicology
San Francisco Bay Area
Full-time
Onsite
Mid, Senior Level
$149K/yr - $186K/yr
3+ years expRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The role involves leading investigative safety strategies for small molecules and collaborating across teams to advance oncology drug development.
Health CareLife ScienceMedical
Responsibilities
Function primarily as an investigative toxicologist to develop and deliver novel approach methods (NAMs) including predictive 2D and 3D models for nonclinical safety assessments
Design, execute and deliver in vitro/ex vivo assays to detect and derisk toxicities for candidate drug molecules
Assess new technologies to support/improve compound toxicity prediction & screening, and development of translational/safety biomarkers
Design, analyze and oversee in vivo studies to better understand mechanisms of toxicity and help develop mitigation strategies of our pipeline
Partner with internal and external collaborators and stakeholders related to integrated large-scale data analytics, computational and chemical mining efforts
Function as a project toxicologist on drug discovery and development project teams and be a strong advocate for patient safety
Design and oversee nonclinical toxicology programs to advance pipeline of small molecule cancer therapeutics by implementing target de-risking, screening, in vivo testing strategies, risk mitigation, and investigation of toxicities
Effectively implement and oversee studies outsourced to CROs, in collaboration with RevMed study operations, pharmacology, DMPK and clinical pharmacology functions
Analyze, interpret, and summarize nonclinical safety data, and present and contextualize meaningful findings with recommendations to internal project teams and RevMed leadership
Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making, including drafting and reviewing of nonclinical sections of regulatory documents
Qualification
Required
Ph.D. degree in Toxicology, Pharmacology, Immunology, Cancer biology or related discipline with 3+ years of relevant biotech/pharma drug discovery/development experience in a team-facing role
Strong scientific background and scientific aptitude, with excellent critical thinking and creative problem-solving skills
Ability to work effectively, independently and collaboratively on cross-functional project teams; demonstrated ability to multitask, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important
Experience with advanced cell culture approaches with immortalized cell lines, primary cells, whole blood, PBMCs and iPSC cells
Cell and molecular biology techniques including flow cytometry, Luminex/MSD, ELISA, and biomarker assay development and validation
Proven expertise in 3D cell culture systems such as tumor spheroids, organoids, complex in vitro models and organ-on-a-chip models
Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including small molecule drugs, for biomarker development and application, and for derisking drug candidates
Experience working in a matrixed team environment at a biotech/pharma company or CRO
Familiarity with GLPs and FDA/ICH guidance documents for nonclinical toxicology/safety pharmacology regulatory submissions
Excellent verbal, oral and written communication skills
Strong interpersonal and organizational skills
Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, biotech company environment
Preferred
Experience working with small molecules and targeted oncology therapeutics of all modalities
Experience with skin, cardiovascular, gastrointestinal, or immunotoxicity assays is desirable
Experience preparing study reports and nonclinical safety sections supporting submissions (e.g. IND/NDA, IB, DSUR)
Benefits
Competitive cash compensation
Robust equity awards
Strong benefits
Significant learning and development opportunities
Company
Revolution Medicines
Revolution Medicines is an innovative and dynamic organization of expert biologists, chemists, pharmacologists, clinical scientists.
501-1000 employees
H1B Sponsorship
Revolution Medicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (13)
2024 (18)
2023 (15)
2022 (8)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$2.25BKey Investors
Royalty PharmaBoxer CapitalNextech Invest
2025-06-24Post Ipo Debt· $250M
2024-12-02Post Ipo Equity· $750M
2023-03-02Post Ipo Equity· $323.6M
Leadership Team
Luan Wilfong
Chief Human Resources Officer
Steve Kelsey
President
Recent News
2026-01-09
2026-01-09
Company data provided by crunchbase